Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1255208..1255828 Replicon chromosome
Accession NZ_CP099377
Organism Citrobacter braakii strain RHB23-SO-C01

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK19_RS05930 Protein ID WP_002892050.1
Coordinates 1255208..1255426 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag NFK19_RS05935 Protein ID WP_019076175.1
Coordinates 1255454..1255828 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK19_RS05895 (1250567) 1250567..1251196 + 630 WP_049270150.1 membrane protein -
NFK19_RS05900 (1251261) 1251261..1251614 + 354 WP_003831033.1 DUF1428 family protein -
NFK19_RS05905 (1251666) 1251666..1253219 - 1554 WP_279266861.1 EAL domain-containing protein -
NFK19_RS05910 (1253408) 1253408..1253668 + 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFK19_RS05915 (1253670) 1253670..1253810 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK19_RS05920 (1253889) 1253889..1254359 - 471 WP_016152071.1 YlaC family protein -
NFK19_RS05925 (1254476) 1254476..1255027 - 552 WP_019076174.1 maltose O-acetyltransferase -
NFK19_RS05930 (1255208) 1255208..1255426 - 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK19_RS05935 (1255454) 1255454..1255828 - 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
NFK19_RS05940 (1256316) 1256316..1259465 - 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFK19_RS05945 (1259488) 1259488..1260681 - 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248729 WP_002892050.1 NZ_CP099377:c1255426-1255208 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT248729 WP_019076175.1 NZ_CP099377:c1255828-1255454 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References