Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4071016..4071670 Replicon chromosome
Accession NZ_CP099376
Organism Citrobacter braakii strain RHB23-SO-C04

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFK21_RS19395 Protein ID WP_016154348.1
Coordinates 4071016..4071423 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFK21_RS19400 Protein ID WP_016154349.1
Coordinates 4071404..4071670 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK21_RS19375 (4066908) 4066908..4068641 - 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -
NFK21_RS19380 (4068647) 4068647..4069360 - 714 WP_279266595.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK21_RS19385 (4069384) 4069384..4070280 - 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFK21_RS19390 (4070394) 4070394..4070915 + 522 WP_279266596.1 flavodoxin FldB -
NFK21_RS19395 (4071016) 4071016..4071423 - 408 WP_016154348.1 protein YgfX Toxin
NFK21_RS19400 (4071404) 4071404..4071670 - 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFK21_RS19405 (4071928) 4071928..4072908 + 981 WP_016154350.1 tRNA-modifying protein YgfZ -
NFK21_RS19410 (4072988) 4072988..4073647 - 660 WP_016154351.1 hemolysin III family protein -
NFK21_RS19415 (4073811) 4073811..4074122 - 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFK21_RS19420 (4074175) 4074175..4074903 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFK21_RS19425 (4075024) 4075024..4076457 + 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248725 WP_016154348.1 NZ_CP099376:c4071423-4071016 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248725 WP_016154349.1 NZ_CP099376:c4071670-4071404 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References