Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2533926..2534562 Replicon chromosome
Accession NZ_CP099376
Organism Citrobacter braakii strain RHB23-SO-C04

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NFK21_RS12080 Protein ID WP_137379723.1
Coordinates 2534374..2534562 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFK21_RS12075 Protein ID WP_131341011.1
Coordinates 2533926..2534342 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK21_RS12055 (2528971) 2528971..2529915 - 945 WP_016153152.1 ABC transporter permease -
NFK21_RS12060 (2529916) 2529916..2530932 - 1017 WP_053389782.1 ABC transporter ATP-binding protein -
NFK21_RS12065 (2530949) 2530949..2532094 - 1146 WP_075848180.1 ABC transporter substrate-binding protein -
NFK21_RS12070 (2532424) 2532424..2533833 - 1410 WP_137379724.1 PLP-dependent aminotransferase family protein -
NFK21_RS12075 (2533926) 2533926..2534342 - 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFK21_RS12080 (2534374) 2534374..2534562 - 189 WP_137379723.1 type II toxin-antitoxin system HicA family toxin Toxin
NFK21_RS12085 (2534826) 2534826..2536229 + 1404 WP_016153156.1 cytochrome ubiquinol oxidase subunit I -
NFK21_RS12090 (2536229) 2536229..2537239 + 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFK21_RS12095 (2537239) 2537239..2537364 + 126 WP_003020230.1 DUF2474 domain-containing protein -
NFK21_RS12100 (2537554) 2537554..2537784 + 231 WP_016153158.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7175.25 Da        Isoelectric Point: 11.8399

>T248724 WP_137379723.1 NZ_CP099376:c2534562-2534374 [Citrobacter braakii]
VKQSEFRRWLESQGVAITNGSNHLKLRYQGRRSVMPRHRGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT248724 WP_131341011.1 NZ_CP099376:c2534342-2533926 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References