248712

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4295447..4296023 Replicon chromosome
Accession NZ_CP099375
Organism Citrobacter braakii strain RHB25-E4-C05

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag NFK28_RS20720 Protein ID WP_053389309.1
Coordinates 4295736..4296023 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A7L6U766
Locus tag NFK28_RS20715 Protein ID WP_046275900.1
Coordinates 4295447..4295749 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK28_RS20700 (4291942) 4291942..4292136 + 195 WP_003830038.1 YbdD/YjiX family protein -
NFK28_RS20705 (4292149) 4292149..4293105 + 957 WP_053389311.1 GTPase -
NFK28_RS20710 (4293292) 4293292..4295139 + 1848 WP_279278152.1 NERD domain-containing protein/DEAD/DEAH box helicase -
NFK28_RS20715 (4295447) 4295447..4295749 - 303 WP_046275900.1 BrnA antitoxin family protein Antitoxin
NFK28_RS20720 (4295736) 4295736..4296023 - 288 WP_053389309.1 BrnT family toxin Toxin
NFK28_RS20725 (4296254) 4296254..4297420 + 1167 WP_019078303.1 restriction endonuclease -
NFK28_RS20730 (4297516) 4297516..4299945 + 2430 WP_053389308.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(46-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11307.71 Da        Isoelectric Point: 7.5237

>T248712 WP_053389309.1 NZ_CP099375:c4296023-4295736 [Citrobacter braakii]
MPMEFEWDANKAQSNHRKHGIRFEDAILVFDDPQHLSRQDRYENGEYRWQTIGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERSRYEHS

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11503.10 Da        Isoelectric Point: 9.5650

>AT248712 WP_046275900.1 NZ_CP099375:c4295749-4295447 [Citrobacter braakii]
MNIVKHKRGSVSALSAQHEAELKALANKPDDDIDYSDIPVTEDELWSEAHRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U766

References