248711

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3717982..3718602 Replicon chromosome
Accession NZ_CP099375
Organism Citrobacter braakii strain RHB25-E4-C05

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK28_RS18045 Protein ID WP_002892050.1
Coordinates 3718384..3718602 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag NFK28_RS18040 Protein ID WP_019076175.1
Coordinates 3717982..3718356 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK28_RS18030 (3713129) 3713129..3714322 + 1194 WP_053389373.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK28_RS18035 (3714345) 3714345..3717494 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFK28_RS18040 (3717982) 3717982..3718356 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
NFK28_RS18045 (3718384) 3718384..3718602 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK28_RS18050 (3718783) 3718783..3719334 + 552 WP_016152072.1 maltose O-acetyltransferase -
NFK28_RS18055 (3719451) 3719451..3719921 + 471 WP_016152071.1 YlaC family protein -
NFK28_RS18060 (3720000) 3720000..3720140 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK28_RS18065 (3720142) 3720142..3720402 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFK28_RS18070 (3720591) 3720591..3722144 + 1554 WP_053388979.1 EAL domain-containing protein -
NFK28_RS18075 (3722196) 3722196..3722549 - 354 WP_003831033.1 DUF1428 family protein -
NFK28_RS18080 (3722614) 3722614..3723243 - 630 WP_049270150.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248711 WP_002892050.1 NZ_CP099375:3718384-3718602 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT248711 WP_019076175.1 NZ_CP099375:3717982-3718356 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References