Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2525931..2526567 Replicon chromosome
Accession NZ_CP099375
Organism Citrobacter braakii strain RHB25-E4-C05

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag NFK28_RS12395 Protein ID WP_049259794.1
Coordinates 2525931..2526119 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFK28_RS12400 Protein ID WP_131382557.1
Coordinates 2526151..2526567 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK28_RS12375 (2522709) 2522709..2522939 - 231 WP_016153158.1 DUF2554 family protein -
NFK28_RS12380 (2523129) 2523129..2523254 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFK28_RS12385 (2523254) 2523254..2524264 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFK28_RS12390 (2524264) 2524264..2525667 - 1404 WP_016153156.1 cytochrome ubiquinol oxidase subunit I -
NFK28_RS12395 (2525931) 2525931..2526119 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
NFK28_RS12400 (2526151) 2526151..2526567 + 417 WP_131382557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFK28_RS12405 (2526660) 2526660..2528069 + 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
NFK28_RS12410 (2528399) 2528399..2529544 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFK28_RS12415 (2529561) 2529561..2530577 + 1017 WP_053389782.1 ABC transporter ATP-binding protein -
NFK28_RS12420 (2530578) 2530578..2531522 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248705 WP_049259794.1 NZ_CP099375:2525931-2526119 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT248705 WP_131382557.1 NZ_CP099375:2526151-2526567 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References