248704

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1025191..1025852 Replicon chromosome
Accession NZ_CP099375
Organism Citrobacter braakii strain RHB25-E4-C05

Toxin (Protein)


Gene name ypjF Uniprot ID S3IMJ6
Locus tag NFK28_RS05085 Protein ID WP_000698542.1
Coordinates 1025529..1025852 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID S3J179
Locus tag NFK28_RS05080 Protein ID WP_000065326.1
Coordinates 1025191..1025508 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK28_RS05035 (1020331) 1020331..1021155 + 825 WP_000197385.1 DUF932 domain-containing protein -
NFK28_RS05040 (1021364) 1021364..1022074 + 711 WP_024198336.1 hypothetical protein -
NFK28_RS05045 (1022100) 1022100..1022636 + 537 WP_000219797.1 DUF4339 domain-containing protein -
NFK28_RS05050 (1022678) 1022678..1023115 + 438 WP_024198335.1 hypothetical protein -
NFK28_RS05055 (1023182) 1023182..1023592 + 411 WP_000912997.1 hypothetical protein -
NFK28_RS05060 (1023670) 1023670..1023906 + 237 WP_000004273.1 DUF905 domain-containing protein -
NFK28_RS05065 (1023992) 1023992..1024450 + 459 WP_016538084.1 antirestriction protein -
NFK28_RS05070 (1024466) 1024466..1024942 + 477 WP_000811694.1 RadC family protein -
NFK28_RS05075 (1024951) 1024951..1025172 + 222 WP_000691995.1 DUF987 domain-containing protein -
NFK28_RS05080 (1025191) 1025191..1025508 + 318 WP_000065326.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFK28_RS05085 (1025529) 1025529..1025852 + 324 WP_000698542.1 TA system toxin CbtA family protein Toxin
NFK28_RS05090 (1027304) 1027304..1027831 + 528 WP_046274927.1 Vi polysaccharide biosynthesis protein TviA -
NFK28_RS05095 (1028089) 1028089..1029366 + 1278 WP_016157409.1 Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB -
NFK28_RS05100 (1029369) 1029369..1030409 + 1041 WP_053389486.1 Vi polysaccharide biosynthesis UDP-N-acetylglucosaminuronic acid C-4 epimerase TviC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - tviB / tviC 988776..1030409 41633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(6-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12350.38 Da        Isoelectric Point: 8.9789

>T248704 WP_000698542.1 NZ_CP099375:1025529-1025852 [Citrobacter braakii]
MKILPATISRAAKPCLPPVAVWQLLLTRLLEKHYGLTLNDTPFSDETVIKEHFDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTNIDIMRARRDLGLLNRN

Download         Length: 324 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11830.50 Da        Isoelectric Point: 6.9367

>AT248704 WP_000065326.1 NZ_CP099375:1025191-1025508 [Citrobacter braakii]
MSNIIWGLQRDITPRLGTRLVQEGNQLHYLADRACITGKFSDAECLKLDVAFPHFISRMESMLSTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYVAVYSTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3IMJ6

Antitoxin

Source ID Structure
AlphaFold DB S3J179

References