248703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 979294..979948 Replicon chromosome
Accession NZ_CP099375
Organism Citrobacter braakii strain RHB25-E4-C05

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFK28_RS04795 Protein ID WP_016154348.1
Coordinates 979541..979948 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFK28_RS04790 Protein ID WP_016154349.1
Coordinates 979294..979560 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK28_RS04765 (974507) 974507..975940 - 1434 WP_053389494.1 6-phospho-beta-glucosidase BglA -
NFK28_RS04770 (976061) 976061..976789 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFK28_RS04775 (976842) 976842..977153 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFK28_RS04780 (977317) 977317..977976 + 660 WP_016154351.1 hemolysin III family protein -
NFK28_RS04785 (978056) 978056..979036 - 981 WP_053389491.1 tRNA-modifying protein YgfZ -
NFK28_RS04790 (979294) 979294..979560 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFK28_RS04795 (979541) 979541..979948 + 408 WP_016154348.1 protein YgfX Toxin
NFK28_RS04800 (980049) 980049..980570 - 522 WP_016154347.1 flavodoxin FldB -
NFK28_RS04805 (980684) 980684..981580 + 897 WP_046274931.1 site-specific tyrosine recombinase XerD -
NFK28_RS04810 (981604) 981604..982317 + 714 WP_016154345.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK28_RS04815 (982323) 982323..984056 + 1734 WP_053389488.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248703 WP_016154348.1 NZ_CP099375:979541-979948 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248703 WP_016154349.1 NZ_CP099375:979294-979560 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References