248698

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3942245..3942771 Replicon chromosome
Accession NZ_CP099374
Organism Citrobacter braakii strain RHB25-SO-C06

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NFK30_RS19070 Protein ID WP_000323025.1
Coordinates 3942245..3942532 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag NFK30_RS19075 Protein ID WP_004196370.1
Coordinates 3942532..3942771 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK30_RS19020 (3938249) 3938249..3938950 + 702 WP_001548933.1 WYL domain-containing protein -
NFK30_RS19025 (3938991) 3938991..3939227 + 237 WP_001144031.1 protein YpjK -
NFK30_RS19030 (3939227) 3939227..3939670 + 444 WP_001547764.1 lipoprotein YafY -
NFK30_RS19035 (3939694) 3939694..3940161 + 468 WP_001547765.1 protein YkfB -
NFK30_RS19040 (3940238) 3940238..3940477 + 240 WP_000194654.1 DUF905 family protein -
NFK30_RS19045 (3940575) 3940575..3941033 + 459 WP_128317712.1 antirestriction protein -
NFK30_RS19050 (3941049) 3941049..3941525 + 477 WP_000811693.1 RadC family protein -
NFK30_RS19055 (3941534) 3941534..3941755 + 222 WP_000691994.1 DUF987 domain-containing protein -
NFK30_RS19060 (3941774) 3941774..3942091 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW -
NFK30_RS19065 (3942112) 3942112..3942361 + 250 Protein_3736 TA system toxin CbtA family protein -
NFK30_RS19070 (3942245) 3942245..3942532 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NFK30_RS19075 (3942532) 3942532..3942771 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NFK30_RS19080 (3942796) 3942796..3942900 + 105 Protein_3739 protein YdfV -
NFK30_RS19085 (3943034) 3943034..3943957 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
NFK30_RS19090 (3944157) 3944157..3944729 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
NFK30_RS19095 (3945205) 3945205..3946443 - 1239 WP_061283191.1 IS110-like element ISEsa2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T248698 WP_000323025.1 NZ_CP099374:c3942532-3942245 [Citrobacter braakii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT248698 WP_004196370.1 NZ_CP099374:c3942771-3942532 [Citrobacter braakii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References