Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3716746..3717366 Replicon chromosome
Accession NZ_CP099374
Organism Citrobacter braakii strain RHB25-SO-C06

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK30_RS18005 Protein ID WP_002892050.1
Coordinates 3717148..3717366 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFK30_RS18000 Protein ID WP_003021733.1
Coordinates 3716746..3717120 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK30_RS17990 (3711893) 3711893..3713086 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK30_RS17995 (3713109) 3713109..3716258 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFK30_RS18000 (3716746) 3716746..3717120 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFK30_RS18005 (3717148) 3717148..3717366 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK30_RS18010 (3717547) 3717547..3718098 + 552 WP_103283555.1 maltose O-acetyltransferase -
NFK30_RS18015 (3718215) 3718215..3718685 + 471 WP_016152071.1 YlaC family protein -
NFK30_RS18020 (3718764) 3718764..3718904 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK30_RS18025 (3718906) 3718906..3719166 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFK30_RS18030 (3719354) 3719354..3720907 + 1554 WP_109018125.1 EAL domain-containing protein -
NFK30_RS18035 (3720959) 3720959..3721312 - 354 WP_003831033.1 DUF1428 family protein -
NFK30_RS18040 (3721377) 3721377..3722006 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248697 WP_002892050.1 NZ_CP099374:3717148-3717366 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248697 WP_003021733.1 NZ_CP099374:3716746-3717120 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References