Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 868767..869421 Replicon chromosome
Accession NZ_CP099374
Organism Citrobacter braakii strain RHB25-SO-C06

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFK30_RS04210 Protein ID WP_016154348.1
Coordinates 869014..869421 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFK30_RS04205 Protein ID WP_016154349.1
Coordinates 868767..869033 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK30_RS04180 (863980) 863980..865413 - 1434 WP_109017253.1 6-phospho-beta-glucosidase BglA -
NFK30_RS04185 (865534) 865534..866262 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFK30_RS04190 (866315) 866315..866626 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFK30_RS04195 (866790) 866790..867449 + 660 WP_016154351.1 hemolysin III family protein -
NFK30_RS04200 (867529) 867529..868509 - 981 WP_094168631.1 tRNA-modifying protein YgfZ -
NFK30_RS04205 (868767) 868767..869033 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFK30_RS04210 (869014) 869014..869421 + 408 WP_016154348.1 protein YgfX Toxin
NFK30_RS04215 (869522) 869522..870043 - 522 WP_016154347.1 flavodoxin FldB -
NFK30_RS04220 (870157) 870157..871053 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFK30_RS04225 (871077) 871077..871790 + 714 WP_016154345.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK30_RS04230 (871796) 871796..873529 + 1734 WP_109017254.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248690 WP_016154348.1 NZ_CP099374:869014-869421 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248690 WP_016154349.1 NZ_CP099374:868767-869033 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References