Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2196218..2196825 Replicon chromosome
Accession NC_014378
Organism Acetohalobium arabaticum DSM 5501

Toxin (Protein)


Gene name pemK Uniprot ID D9QT85
Locus tag acear_RS10645 Protein ID WP_013279028.1
Coordinates 2196218..2196568 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag acear_RS10650 Protein ID WP_041667735.1
Coordinates 2196571..2196825 (-) Length 85 a.a.

Genomic Context

acear_RS10625acear_RS10630acear_RS10635acear_RS10640acear_RS10645acear_RS10650acear_RS12640acear_RS10655acear_RS10660acear_RS10665
Location: 2191629..2192102 (474 bp)
Type: Others
Protein ID: WP_013279024.1
Location: 2192193..2192699 (507 bp)
Type: Others
Protein ID: WP_013279025.1
Location: 2192720..2194909 (2190 bp)
Type: Others
Protein ID: WP_013279026.1
Location: 2194935..2196134 (1200 bp)
Type: Others
Protein ID: WP_013279027.1
Location: 2196218..2196568 (351 bp)
Type: Toxin
Protein ID: WP_013279028.1
Location: 2196571..2196825 (255 bp)
Type: Antitoxin
Protein ID: WP_041667735.1
Location: 2197053..2197226 (174 bp)
Type: Others
Protein ID: WP_013279030.1
Location: 2197361..2199604 (2244 bp)
Type: Others
Protein ID: WP_013279031.1
Location: 2199709..2200374 (666 bp)
Type: Others
Protein ID: WP_013279032.1
Location: 2200385..2200831 (447 bp)
Type: Others
Protein ID: WP_013279033.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
acear_RS106252191629..2192102-474WP_013279024.1tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE-
acear_RS106302192193..2192699-507WP_013279025.1ECF transporter S component-
acear_RS106352192720..2194909-2190WP_013279026.1tetratricopeptide repeat protein-
acear_RS106402194935..2196134-1200WP_013279027.1amidohydrolase-
acear_RS106452196218..2196568-351WP_013279028.1type II toxin-antitoxin system PemK/MazF family toxinToxin
acear_RS106502196571..2196825-255WP_041667735.1ribbon-helix-helix protein, CopG familyAntitoxin
acear_RS126402197053..2197226-174WP_013279030.1hypothetical protein-
acear_RS106552197361..2199604-2244WP_013279031.1IGHMBP2 family helicase-
acear_RS106602199709..2200374-666WP_013279032.1isoprenoid biosynthesis glyoxalase ElbB-
acear_RS106652200385..2200831-447WP_013279033.1CBS domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12890.85 Da        Isoelectric Point: 6.2341

>T24869 WP_013279028.1 NC_014378:c2196568-2196218 [Acetohalobium arabaticum DSM 5501]
VAIKRGDVFYADLNPVVGSEQGGIRPVLVIQNDIGNKYSPTVIVAAITSKIKKGKLPTHVEIDSNEHNLDKDSVILLEQI
RTIDKKRLRRQVTHLNEEIVKDVDEALEISVGLIDL

Download         Length: 351 bp

>T24869 NC_014378:c2196568-2196218 [Acetohalobium arabaticum DSM 5501]
GTGGCTATCAAACGAGGCGATGTATTTTATGCAGATTTGAATCCGGTAGTCGGTTCTGAACAGGGAGGAATAAGACCGGT
ATTAGTAATTCAGAATGATATAGGTAATAAATATAGTCCTACTGTAATTGTGGCAGCCATTACTTCTAAGATCAAGAAAG
GAAAACTGCCTACTCATGTAGAGATAGACTCTAATGAGCATAATTTAGATAAGGATTCAGTAATTCTTTTAGAACAGATT
AGAACCATTGATAAGAAGCGGCTGCGCAGGCAGGTTACTCATTTAAATGAAGAGATAGTTAAAGATGTAGATGAAGCTTT
AGAGATTAGCGTTGGTCTAATCGATTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9854.14 Da        Isoelectric Point: 4.3103

>AT24869 WP_041667735.1 NC_014378:c2196825-2196571 [Acetohalobium arabaticum DSM 5501]
MISLPDSLLEKVDGVAEQENQNRSEFVRKAMKLYIAELRKEEIKQEMKQGYLEMGNINLEIAEDNIRIENRDFSKYEANI
AECE

Download         Length: 255 bp

>AT24869 NC_014378:c2196825-2196571 [Acetohalobium arabaticum DSM 5501]
ATGATTAGCTTGCCGGATAGTTTATTAGAAAAGGTAGATGGGGTTGCCGAACAAGAGAATCAAAACCGCAGTGAGTTTGT
GCGTAAAGCTATGAAGCTCTATATTGCTGAGCTGCGTAAAGAAGAGATTAAACAGGAGATGAAGCAGGGCTATTTAGAAA
TGGGGAATATTAATTTAGAAATAGCAGAAGATAATATCAGGATAGAGAATAGAGACTTTTCAAAGTATGAAGCTAATATT
GCGGAGTGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD9QT85

Antitoxin

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Source
ID
Structure
No matching records found

References