248688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4817730..4818265 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NFK58_RS23210 Protein ID WP_085049650.1
Coordinates 4817978..4818265 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4BKM9
Locus tag NFK58_RS23205 Protein ID WP_006688247.1
Coordinates 4817730..4817981 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK58_RS23175 (NFK58_23195) 4813207..4813965 + 759 WP_123269099.1 phosphonate C-P lyase system protein PhnK -
NFK58_RS23180 (NFK58_23200) 4814087..4814773 + 687 WP_137382890.1 phosphonate C-P lyase system protein PhnL -
NFK58_RS23185 (NFK58_23205) 4814770..4815906 + 1137 WP_126957331.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
NFK58_RS23190 (NFK58_23210) 4815909..4816463 + 555 WP_079938996.1 ribose 1,5-bisphosphokinase -
NFK58_RS23195 (NFK58_23215) 4816450..4816884 + 435 WP_123269102.1 aminoalkylphosphonate N-acetyltransferase -
NFK58_RS23200 (NFK58_23220) 4816893..4817651 + 759 WP_191227901.1 phosphonate metabolism protein PhnP -
NFK58_RS23205 (NFK58_23225) 4817730..4817981 + 252 WP_006688247.1 plasmid stabilization protein Antitoxin
NFK58_RS23210 (NFK58_23230) 4817978..4818265 + 288 WP_085049650.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK58_RS23215 (NFK58_23235) 4818262..4818591 - 330 WP_137361135.1 DDRRRQL repeat protein YjdP -
NFK58_RS23220 (NFK58_23240) 4818660..4819292 - 633 WP_123269105.1 GNAT family N-acetyltransferase -
NFK58_RS23225 (NFK58_23245) 4819468..4821741 - 2274 WP_123269106.1 hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11089.04 Da        Isoelectric Point: 10.3527

>T248688 WP_085049650.1 NZ_CP099373:4817978-4818265 [Citrobacter portucalensis]
MSYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCENPHVPSAKLRGIKDCYKIKLRTSGFRLVYQVIDDTLVIAVVAVGK
RERSEVYNLASERLR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9215.53 Da        Isoelectric Point: 4.2965

>AT248688 WP_006688247.1 NZ_CP099373:4817730-4817981 [Citrobacter portucalensis]
MPHIILSDTTASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQQLVKLVHERSQQPLVDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1BT32

References