Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4767574..4768377 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6N6JYU3
Locus tag NFK58_RS22975 Protein ID WP_024156451.1
Coordinates 4767997..4768377 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NFK58_RS22970 Protein ID WP_149692527.1
Coordinates 4767574..4767939 (+) Length 122 a.a.

Genomic Context

NFK58_RS22930NFK58_RS22935NFK58_RS22940NFK58_RS22945NFK58_RS22950NFK58_RS22955NFK58_RS22960NFK58_RS22965NFK58_RS22970NFK58_RS22975NFK58_RS22980NFK58_RS22985NFK58_RS22990NFK58_RS22995NFK58_RS23000
Location: 4762647..4763534 (888 bp)
Type: Others
Protein ID: WP_191225903.1
Location: 4763740..4764141 (402 bp)
Type: Others
Protein ID: WP_149692533.1
Location: 4764238..4764705 (468 bp)
Type: Others
Protein ID: WP_149692532.1
Location: 4764896..4765147 (252 bp)
Type: Others
Protein ID: WP_149692531.1
Location: 4765265..4766083 (819 bp)
Type: Others
Protein ID: WP_149692530.1
Location: 4766343..4766825 (483 bp)
Type: Others
Protein ID: WP_149692529.1
Location: 4766838..4767317 (480 bp)
Type: Others
Protein ID: WP_024156448.1
Location: 4767331..4767552 (222 bp)
Type: Others
Protein ID: WP_149692528.1
Location: 4767574..4767939 (366 bp)
Type: Antitoxin
Protein ID: WP_149692527.1
Location: 4767997..4768377 (381 bp)
Type: Toxin
Protein ID: WP_024156451.1
Location: 4768374..4768865 (492 bp)
Type: Others
Protein ID: WP_149692526.1
Location: 4768895..4769091 (197 bp)
Type: Others
Protein ID: Protein_4509
Location: 4769174..4770022 (849 bp)
Type: Others
Protein ID: WP_149692525.1
Location: 4770503..4770697 (195 bp)
Type: Others
Protein ID: WP_123268534.1
Location: 4770780..4772441 (1662 bp)
Type: Others
Protein ID: WP_123268533.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NFK58_RS22930 (NFK58_22950)4762647..4763534+888WP_191225903.150S ribosome-binding GTPase-
NFK58_RS22935 (NFK58_22955)4763740..4764141+402WP_149692533.1hypothetical protein-
NFK58_RS22940 (NFK58_22960)4764238..4764705+468WP_149692532.1hypothetical protein-
NFK58_RS22945 (NFK58_22965)4764896..4765147+252WP_149692531.1DUF905 family protein-
NFK58_RS22950 (NFK58_22970)4765265..4766083+819WP_149692530.1DUF932 domain-containing protein-
NFK58_RS22955 (NFK58_22975)4766343..4766825+483WP_149692529.1antirestriction protein-
NFK58_RS22960 (NFK58_22980)4766838..4767317+480WP_024156448.1DNA repair protein RadC-
NFK58_RS22965 (NFK58_22985)4767331..4767552+222WP_149692528.1DUF987 domain-containing protein-
NFK58_RS22970 (NFK58_22990)4767574..4767939+366WP_149692527.1type IV toxin-antitoxin system YeeU family antitoxinAntitoxin
NFK58_RS22975 (NFK58_22995)4767997..4768377+381WP_024156451.1TA system toxin CbtA family proteinToxin
NFK58_RS22980 (NFK58_23000)4768374..4768865+492WP_149692526.1DUF5983 family protein-
NFK58_RS22985 (NFK58_23005)4768895..4769091+197Protein_4509hypothetical protein-
NFK58_RS22990 (NFK58_23010)4769174..4770022+849WP_149692525.1DUF4942 domain-containing protein-
NFK58_RS22995 (NFK58_23015)4770503..4770697+195WP_123268534.1hypothetical protein-
NFK58_RS23000 (NFK58_23020)4770780..4772441+1662WP_123268533.1fatty acid--CoA ligase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14263.44 Da        Isoelectric Point: 10.0919

>T248687 WP_024156451.1 NZ_CP099373:4767997-4768377 [Citrobacter portucalensis]
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13458.29 Da        Isoelectric Point: 6.2044

>AT248687 WP_149692527.1 NZ_CP099373:4767574-4767939 [Citrobacter portucalensis]
MSNQLPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIASVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PRHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6N6JYU3

Antitoxin

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Source
ID
Structure
No matching records found

References