248686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4621030..4621546 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name relE Uniprot ID A0A6H3ATC4
Locus tag NFK58_RS22175 Protein ID WP_048227188.1
Coordinates 4621030..4621314 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6H3AWC7
Locus tag NFK58_RS22180 Protein ID WP_003830370.1
Coordinates 4621304..4621546 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK58_RS22160 (NFK58_22180) 4616241..4617893 + 1653 WP_123268582.1 alpha,alpha-phosphotrehalase -
NFK58_RS22165 (NFK58_22185) 4618303..4620441 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
NFK58_RS22170 (NFK58_22190) 4620562..4621026 + 465 WP_048227187.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFK58_RS22175 (NFK58_22195) 4621030..4621314 - 285 WP_048227188.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK58_RS22180 (NFK58_22200) 4621304..4621546 - 243 WP_003830370.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFK58_RS22185 (NFK58_22205) 4621624..4623537 - 1914 WP_191227861.1 BglG family transcription antiterminator -
NFK58_RS22190 (NFK58_22210) 4623559..4624299 - 741 WP_191227862.1 KDGP aldolase family protein -
NFK58_RS22195 (NFK58_22215) 4624296..4625414 - 1119 WP_128316769.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NFK58_RS22200 (NFK58_22220) 4625398..4626531 - 1134 WP_123268580.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10918.71 Da        Isoelectric Point: 10.0482

>T248686 WP_048227188.1 NZ_CP099373:c4621314-4621030 [Citrobacter portucalensis]
MTYELEFDPRALKEWHKLGDTVKTQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVVVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8945.35 Da        Isoelectric Point: 5.0651

>AT248686 WP_003830370.1 NZ_CP099373:c4621546-4621304 [Citrobacter portucalensis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H3ATC4

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AWC7

References