248684

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3890912..3891532 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK58_RS18750 Protein ID WP_002892050.1
Coordinates 3891314..3891532 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFK58_RS18745 Protein ID WP_003021733.1
Coordinates 3890912..3891286 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK58_RS18735 (NFK58_18755) 3886059..3887252 + 1194 WP_279267828.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK58_RS18740 (NFK58_18760) 3887275..3890424 + 3150 WP_063941319.1 efflux RND transporter permease AcrB -
NFK58_RS18745 (NFK58_18765) 3890912..3891286 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFK58_RS18750 (NFK58_18770) 3891314..3891532 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK58_RS18755 (NFK58_18775) 3891714..3892265 + 552 WP_123268449.1 maltose O-acetyltransferase -
NFK58_RS18760 (NFK58_18780) 3892382..3892852 + 471 WP_020996574.1 YlaC family protein -
NFK58_RS18765 (NFK58_18785) 3892931..3893071 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK58_RS18770 (NFK58_18790) 3893073..3893333 - 261 WP_079938360.1 type B 50S ribosomal protein L31 -
NFK58_RS18775 (NFK58_18795) 3893522..3895075 + 1554 WP_191227645.1 EAL domain-containing protein -
NFK58_RS18780 (NFK58_18800) 3895127..3895480 - 354 WP_003831033.1 DUF1428 family protein -
NFK58_RS18785 (NFK58_18805) 3895545..3896174 - 630 WP_123268450.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248684 WP_002892050.1 NZ_CP099373:3891314-3891532 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248684 WP_003021733.1 NZ_CP099373:3890912-3891286 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References