248683

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2678041..2678777 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NFK58_RS12740 Protein ID WP_123267182.1
Coordinates 2678295..2678777 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag NFK58_RS12735 Protein ID WP_191227292.1
Coordinates 2678041..2678307 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK58_RS12715 (NFK58_12740) 2673085..2674272 + 1188 WP_191227289.1 outer membrane protein transport protein -
NFK58_RS12720 (NFK58_12745) 2674512..2675141 + 630 WP_079937883.1 winged helix-turn-helix transcriptional regulator -
NFK58_RS12725 (NFK58_12750) 2675263..2675649 - 387 WP_191227290.1 hypothetical protein -
NFK58_RS12730 (NFK58_12755) 2675904..2677886 + 1983 WP_275396633.1 alkyl sulfatase dimerization domain-containing protein -
NFK58_RS12735 (NFK58_12760) 2678041..2678307 + 267 WP_191227292.1 DUF1778 domain-containing protein Antitoxin
NFK58_RS12740 (NFK58_12765) 2678295..2678777 + 483 WP_123267182.1 GNAT family N-acetyltransferase Toxin
NFK58_RS12745 (NFK58_12770) 2679064..2679606 + 543 WP_279267723.1 hypothetical protein -
NFK58_RS12750 (NFK58_12775) 2679591..2679836 + 246 WP_279267724.1 DUF3850 domain-containing protein -
NFK58_RS12755 (NFK58_12780) 2679833..2680066 + 234 WP_279267725.1 hypothetical protein -
NFK58_RS12760 (NFK58_12785) 2680074..2680301 + 228 WP_279267726.1 hypothetical protein -
NFK58_RS12765 (NFK58_12790) 2680314..2680607 + 294 WP_279267727.1 hypothetical protein -
NFK58_RS12770 (NFK58_12795) 2680600..2681310 + 711 WP_279267728.1 hypothetical protein -
NFK58_RS12775 (NFK58_12800) 2681379..2681645 + 267 WP_279267729.1 helix-turn-helix transcriptional regulator -
NFK58_RS12780 (NFK58_12805) 2681632..2681979 + 348 WP_279267730.1 hypothetical protein -
NFK58_RS12785 (NFK58_12810) 2681976..2682857 + 882 WP_279267731.1 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2674512..2715180 40668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17711.56 Da        Isoelectric Point: 10.1381

>T248683 WP_123267182.1 NZ_CP099373:2678295-2678777 [Citrobacter portucalensis]
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTNTRQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSVRRKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10141.61 Da        Isoelectric Point: 4.6558

>AT248683 WP_191227292.1 NZ_CP099373:2678041-2678307 [Citrobacter portucalensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEIACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References