248682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2575991..2576630 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NFK58_RS12310 Protein ID WP_123267234.1
Coordinates 2575991..2576167 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFK58_RS12315 Protein ID WP_123267772.1
Coordinates 2576214..2576630 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK58_RS12290 (NFK58_12315) 2572769..2572999 - 231 WP_123267237.1 DUF2554 family protein -
NFK58_RS12295 (NFK58_12320) 2573189..2573314 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFK58_RS12300 (NFK58_12325) 2573314..2574324 - 1011 WP_191228722.1 cytochrome d ubiquinol oxidase subunit II -
NFK58_RS12305 (NFK58_12330) 2574324..2575727 - 1404 WP_191228723.1 cytochrome ubiquinol oxidase subunit I -
NFK58_RS12310 (NFK58_12335) 2575991..2576167 + 177 WP_123267234.1 type II toxin-antitoxin system HicA family toxin Toxin
NFK58_RS12315 (NFK58_12340) 2576214..2576630 + 417 WP_123267772.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFK58_RS12320 (NFK58_12345) 2576723..2578132 + 1410 WP_123267233.1 PLP-dependent aminotransferase family protein -
NFK58_RS12325 (NFK58_12350) 2578461..2579606 + 1146 WP_191228724.1 ABC transporter substrate-binding protein -
NFK58_RS12330 (NFK58_12355) 2579623..2580639 + 1017 WP_063940776.1 ABC transporter ATP-binding protein -
NFK58_RS12335 (NFK58_12360) 2580640..2581584 + 945 WP_191228725.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-66)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6784.81 Da        Isoelectric Point: 11.3242

>T248682 WP_123267234.1 NZ_CP099373:2575991-2576167 [Citrobacter portucalensis]
VKQSEFRRWLESQGVEVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIQKQLGLK

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.28 Da        Isoelectric Point: 4.3529

>AT248682 WP_123267772.1 NZ_CP099373:2576214-2576630 [Citrobacter portucalensis]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHEALQAAQGALVTAFEFYFDDNEPIPLPSAVGTEADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLQHATKIDAVQIAARALGKELSLTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References