248677

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1337489..1338147 Replicon chromosome
Accession NZ_CP099373
Organism Citrobacter portucalensis strain RHB38-SO-C05

Toxin (Protein)


Gene name ypjF Uniprot ID A0A806ZJD4
Locus tag NFK58_RS06425 Protein ID WP_071883340.1
Coordinates 1337489..1337809 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A806NTI2
Locus tag NFK58_RS06430 Protein ID WP_043082396.1
Coordinates 1337830..1338147 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK58_RS06395 (NFK58_06425) 1332817..1333707 + 891 WP_123268140.1 myo-inosose-2 dehydratase -
NFK58_RS06400 (NFK58_06430) 1333717..1334535 + 819 WP_191228300.1 5-deoxy-glucuronate isomerase -
NFK58_RS06405 (NFK58_06435) 1334731..1335087 - 357 WP_003826111.1 hypothetical protein -
NFK58_RS06410 (NFK58_06440) 1335984..1336184 - 201 WP_079939236.1 DUF4926 domain-containing protein -
NFK58_RS06415 (NFK58_06445) 1336195..1336905 - 711 Protein_1257 hypothetical protein -
NFK58_RS06420 (NFK58_06450) 1336999..1337124 - 126 Protein_1258 integrase -
NFK58_RS06425 (NFK58_06455) 1337489..1337809 - 321 WP_071883340.1 TA system toxin CbtA family protein Toxin
NFK58_RS06430 (NFK58_06460) 1337830..1338147 - 318 WP_043082396.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFK58_RS06435 (NFK58_06465) 1338166..1338387 - 222 WP_000691995.1 DUF987 domain-containing protein -
NFK58_RS06440 (NFK58_06470) 1338396..1338872 - 477 WP_043082397.1 RadC family protein -
NFK58_RS06445 (NFK58_06475) 1338888..1339346 - 459 WP_043082398.1 antirestriction protein -
NFK58_RS06450 (NFK58_06480) 1339427..1339663 - 237 WP_071883341.1 DUF905 domain-containing protein -
NFK58_RS06455 (NFK58_06485) 1339741..1340151 - 411 WP_043082399.1 hypothetical protein -
NFK58_RS06460 (NFK58_06490) 1340241..1340855 - 615 WP_043082400.1 hypothetical protein -
NFK58_RS06465 (NFK58_06495) 1340852..1341556 - 705 WP_043082401.1 WYL domain-containing protein -
NFK58_RS06470 (NFK58_06500) 1341758..1342591 - 834 WP_279267912.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1336195..1362270 26075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-104)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12032.98 Da        Isoelectric Point: 7.1339

>T248677 WP_071883340.1 NZ_CP099373:c1337809-1337489 [Citrobacter portucalensis]
MKTLPATTLRAAKPCPSPVIVWQTLLSCLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPFITAVDILKARRAMREMRT

Download         Length: 321 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12053.65 Da        Isoelectric Point: 6.6251

>AT248677 WP_043082396.1 NZ_CP099373:c1338147-1337830 [Citrobacter portucalensis]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHTHCVILYH
NGFTCEADTLGSCGYVYITVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806ZJD4

Antitoxin

Source ID Structure
AlphaFold DB A0A806NTI2

References