Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3882565..3883185 Replicon chromosome
Accession NZ_CP099370
Organism Citrobacter portucalensis strain RHB40-E3-C01

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK62_RS19385 Protein ID WP_002892050.1
Coordinates 3882967..3883185 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFK62_RS19380 Protein ID WP_003021733.1
Coordinates 3882565..3882939 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK62_RS19370 (3877710) 3877710..3878903 + 1194 WP_003831044.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK62_RS19375 (3878926) 3878926..3882075 + 3150 WP_126319003.1 efflux RND transporter permease AcrB -
NFK62_RS19380 (3882565) 3882565..3882939 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFK62_RS19385 (3882967) 3882967..3883185 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK62_RS19390 (3883367) 3883367..3883918 + 552 WP_191219543.1 maltose O-acetyltransferase -
NFK62_RS19395 (3884035) 3884035..3884505 + 471 WP_020996574.1 YlaC family protein -
NFK62_RS19400 (3884584) 3884584..3884724 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK62_RS19405 (3884726) 3884726..3884986 - 261 WP_008783961.1 type B 50S ribosomal protein L31 -
NFK62_RS19410 (3885175) 3885175..3886728 + 1554 WP_279275117.1 EAL domain-containing protein -
NFK62_RS19415 (3886780) 3886780..3887133 - 354 WP_003831033.1 DUF1428 family protein -
NFK62_RS19420 (3887198) 3887198..3887827 - 630 WP_279275118.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248672 WP_002892050.1 NZ_CP099370:3882967-3883185 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248672 WP_003021733.1 NZ_CP099370:3882565-3882939 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References