Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3882565..3883185 Replicon chromosome
Accession NZ_CP099367
Organism Citrobacter portucalensis strain RHB40-E3-C05

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK63_RS19380 Protein ID WP_002892050.1
Coordinates 3882967..3883185 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFK63_RS19375 Protein ID WP_003021733.1
Coordinates 3882565..3882939 (+) Length 125 a.a.

Genomic Context


NFK63_RS19365NFK63_RS19370NFK63_RS19375NFK63_RS19380NFK63_RS19385NFK63_RS19390NFK63_RS19405NFK63_RS19395NFK63_RS19400NFK63_RS19410NFK63_RS19415
Location: 3877710..3878903 (1194 bp)
Type: Others
Protein ID: WP_003831044.1
Location: 3878926..3882075 (3150 bp)
Type: Others
Protein ID: WP_126319003.1
Location: 3882565..3882939 (375 bp)
Type: Antitoxin
Protein ID: WP_003021733.1
Location: 3882967..3883185 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Location: 3883367..3883918 (552 bp)
Type: Others
Protein ID: WP_191219543.1
Location: 3884035..3884505 (471 bp)
Type: Others
Protein ID: WP_020996574.1
Location: 3885175..3886728 (1554 bp)
Type: Others
Protein ID: WP_279275117.1
Location: 3884584..3884724 (141 bp)
Type: Others
Protein ID: WP_005125190.1
Location: 3884726..3884986 (261 bp)
Type: Others
Protein ID: WP_008783961.1
Location: 3886780..3887133 (354 bp)
Type: Others
Protein ID: WP_003831033.1
Location: 3887198..3887827 (630 bp)
Type: Others
Protein ID: WP_279275118.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NFK63_RS19365 (3877710)3877710..3878903+1194WP_003831044.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
NFK63_RS19370 (3878926)3878926..3882075+3150WP_126319003.1efflux RND transporter permease AcrB-
NFK63_RS19375 (3882565)3882565..3882939+375WP_003021733.1Hha toxicity modulator TomBAntitoxin
NFK63_RS19380 (3882967)3882967..3883185+219WP_002892050.1HHA domain-containing proteinToxin
NFK63_RS19385 (3883367)3883367..3883918+552WP_191219543.1maltose O-acetyltransferase-
NFK63_RS19390 (3884035)3884035..3884505+471WP_020996574.1YlaC family protein-
NFK63_RS19395 (3884584)3884584..3884724-141WP_005125190.1type B 50S ribosomal protein L36-
NFK63_RS19400 (3884726)3884726..3884986-261WP_008783961.1type B 50S ribosomal protein L31-
NFK63_RS19405 (3885175)3885175..3886728+1554WP_279275117.1EAL domain-containing protein-
NFK63_RS19410 (3886780)3886780..3887133-354WP_003831033.1DUF1428 family protein-
NFK63_RS19415 (3887198)3887198..3887827-630WP_279275118.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248662 WP_002892050.1 NZ_CP099367:3882967-3883185 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248662 WP_003021733.1 NZ_CP099367:3882565-3882939 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A2P8K6F2


Antitoxin

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Source
ID
Structure
AlphaFold DBR8WZW8

References