Detailed information of TA system TA024866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE-PrpA/ParE-CC2985
• Location: 1440298..1440826
• Replicon: chromosome
• Accession: NC_014375
• Organism: Brevundimonas subvibrioides ATCC 15264

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D9QGF4
• Locus tag: BRESU_RS07185
• Protein ID: WP_013268873.1
• Coordinates: 1440298..1440588 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: -
• Locus tag: BRESU_RS07190
• Protein ID: WP_041762235.1
• Coordinates: 1440581..1440826 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BRESU_RS07165	1436110..1436919	+	810	WP_013268869.1	ABC transporter ATP-binding protein	-
BRESU_RS07170	1436932..1437870	+	939	WP_013268870.1	MCE family protein	-
BRESU_RS07175	1437867..1438472	+	606	WP_013268871.1	membrane integrity-associated transporter subunit PqiC	-
BRESU_RS07180	1438469..1440247	-	1779	WP_013268872.1	patatin-like phospholipase family protein	-
BRESU_RS07185	1440298..1440588	-	291	WP_013268873.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BRESU_RS07190	1440581..1440826	-	246	WP_041762235.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BRESU_RS07195	1440947..1442491	-	1545	WP_013268875.1	serine hydrolase	-
BRESU_RS07200	1442786..1443277	+	492	WP_013268876.1	TIGR01841 family phasin	-
BRESU_RS17135	1443357..1443512	-	156	WP_013268877.1	hypothetical protein	-
BRESU_RS07205	1443716..1444048	+	333	WP_013268878.1	ATP-dependent Clp protease adapter ClpS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (8-80)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11251.90 Da
• Isoelectric Point: 9.5405

>T24866 WP_013268873.1 NC_014375:c1440588-1440298 [Brevundimonas subvibrioides ATCC 15264]
MAEYRLSPRAQRDLADLFDHTVSQWDLDQALRYTDLIDAALARLADAPFRAQACDAIRQGYRRRTVQQHVIYFRPMPYGI
AVIRILHQRMDAARHL

Nucleotide

• Length: 291 bp

>T24866 NC_014375:c1440588-1440298 [Brevundimonas subvibrioides ATCC 15264]
ATGGCTGAGTATCGGCTCAGCCCCCGGGCTCAGCGCGATCTCGCCGACCTTTTTGATCACACCGTGTCCCAGTGGGATCT
GGACCAGGCCCTGCGCTACACGGATCTCATCGACGCCGCTCTCGCCAGACTCGCCGATGCGCCGTTCCGCGCCCAGGCCT
GTGACGCCATCCGGCAGGGCTATCGCCGGCGGACCGTCCAGCAGCATGTCATCTACTTCCGGCCAATGCCTTACGGTATC
GCCGTCATCCGCATCCTGCACCAGCGCATGGACGCGGCCCGTCATCTGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9150.11 Da
• Isoelectric Point: 4.6128

>AT24866 WP_041762235.1 NC_014375:c1440826-1440581 [Brevundimonas subvibrioides ATCC 15264]
VATVRKTITLTVQQDAWIAAQIEAGSYTNDSEAIRDLIRREQERTFEIDTLRQALKEGEQSGEPEPFDFAAFKQQKAAQH
G

Nucleotide

• Length: 246 bp

>AT24866 NC_014375:c1440826-1440581 [Brevundimonas subvibrioides ATCC 15264]
GTGGCCACCGTACGCAAGACGATCACCCTCACCGTGCAGCAGGATGCCTGGATTGCCGCCCAGATCGAGGCGGGCAGCTA
TACCAACGACAGCGAGGCCATCCGCGACCTGATCCGCCGGGAGCAGGAGCGGACGTTCGAGATCGACACGCTTCGACAGG
CCCTCAAGGAGGGCGAACAGAGCGGCGAGCCGGAACCGTTCGATTTCGCCGCCTTCAAACAGCAGAAAGCCGCGCAACAT
GGCTGA

Structures

Toxin

• AlphaFold DB: D9QGF4