248652

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3993884..3994538 Replicon chromosome
Accession NZ_CP099366
Organism Citrobacter braakii strain RHB41-E2-C02

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFK67_RS19210 Protein ID WP_016154348.1
Coordinates 3993884..3994291 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFK67_RS19215 Protein ID WP_016154349.1
Coordinates 3994272..3994538 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK67_RS19190 (NFK67_19185) 3989776..3991509 - 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -
NFK67_RS19195 (NFK67_19190) 3991515..3992228 - 714 WP_016154345.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK67_RS19200 (NFK67_19195) 3992252..3993148 - 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFK67_RS19205 (NFK67_19200) 3993262..3993783 + 522 WP_016154347.1 flavodoxin FldB -
NFK67_RS19210 (NFK67_19205) 3993884..3994291 - 408 WP_016154348.1 protein YgfX Toxin
NFK67_RS19215 (NFK67_19210) 3994272..3994538 - 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFK67_RS19220 (NFK67_19215) 3994796..3995776 + 981 WP_016154350.1 tRNA-modifying protein YgfZ -
NFK67_RS19225 (NFK67_19220) 3995856..3996515 - 660 WP_114681073.1 hemolysin III family protein -
NFK67_RS19230 (NFK67_19225) 3996679..3996990 - 312 WP_279267262.1 N(4)-acetylcytidine aminohydrolase -
NFK67_RS19235 (NFK67_19230) 3997043..3997771 + 729 WP_075847608.1 MurR/RpiR family transcriptional regulator -
NFK67_RS19240 (NFK67_19235) 3997892..3999325 + 1434 WP_279267263.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248652 WP_016154348.1 NZ_CP099366:c3994291-3993884 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248652 WP_016154349.1 NZ_CP099366:c3994538-3994272 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References