248651

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2496145..2496781 Replicon chromosome
Accession NZ_CP099366
Organism Citrobacter braakii strain RHB41-E2-C02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NFK67_RS12040 Protein ID WP_137379723.1
Coordinates 2496593..2496781 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFK67_RS12035 Protein ID WP_131341011.1
Coordinates 2496145..2496561 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK67_RS12015 (NFK67_12010) 2491190..2492134 - 945 WP_016153152.1 ABC transporter permease -
NFK67_RS12020 (NFK67_12015) 2492135..2493151 - 1017 WP_016156582.1 ABC transporter ATP-binding protein -
NFK67_RS12025 (NFK67_12020) 2493168..2494313 - 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFK67_RS12030 (NFK67_12025) 2494643..2496052 - 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
NFK67_RS12035 (NFK67_12030) 2496145..2496561 - 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFK67_RS12040 (NFK67_12035) 2496593..2496781 - 189 WP_137379723.1 type II toxin-antitoxin system HicA family toxin Toxin
NFK67_RS12045 (NFK67_12040) 2497045..2498448 + 1404 WP_016153156.1 cytochrome ubiquinol oxidase subunit I -
NFK67_RS12050 (NFK67_12045) 2498448..2499458 + 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFK67_RS12055 (NFK67_12050) 2499458..2499583 + 126 WP_003020230.1 DUF2474 domain-containing protein -
NFK67_RS12060 (NFK67_12055) 2499773..2500003 + 231 WP_016153158.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7175.25 Da        Isoelectric Point: 11.8399

>T248651 WP_137379723.1 NZ_CP099366:c2496781-2496593 [Citrobacter braakii]
VKQSEFRRWLESQGVAITNGSNHLKLRYQGRRSVMPRHRGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT248651 WP_131341011.1 NZ_CP099366:c2496561-2496145 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References