Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2891932..2892713 Replicon chromosome
Accession NC_014365
Organism Desulfarculus baarsii DSM 2075

Toxin (Protein)


Gene name tacT Uniprot ID E1QK60
Locus tag DEBA_RS12935 Protein ID WP_013259392.1
Coordinates 2892213..2892713 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID E1QK59
Locus tag DEBA_RS12930 Protein ID WP_013259391.1
Coordinates 2891932..2892216 (+) Length 95 a.a.

Genomic Context

DEBA_RS12915DEBA_RS12920DEBA_RS12930DEBA_RS12935DEBA_RS12960DEBA_RS12965DEBA_RS12905DEBA_RS17900DEBA_RS12925DEBA_RS17905DEBA_RS12945DEBA_RS12950DEBA_RS12955
Location: 2889677..2889955 (279 bp)
Type: Others
Protein ID: WP_013259388.1
Location: 2889955..2890458 (504 bp)
Type: Others
Protein ID: WP_013259389.1
Location: 2891932..2892216 (285 bp)
Type: Antitoxin
Protein ID: WP_013259391.1
Location: 2892213..2892713 (501 bp)
Type: Toxin
Protein ID: WP_013259392.1
Location: 2896783..2897121 (339 bp)
Type: Others
Protein ID: WP_013259397.1
Location: 2897105..2897440 (336 bp)
Type: Others
Protein ID: WP_013259398.1
Location: 2887701..2888891 (1191 bp)
Type: Others
Protein ID: WP_187288633.1
Location: 2888897..2889241 (345 bp)
Type: Others
Protein ID: WP_013259387.1
Location: 2890549..2891676 (1128 bp)
Type: Others
Protein ID: WP_013259390.1
Location: 2892843..2895092 (2250 bp)
Type: Others
Protein ID: WP_013259393.1
Location: 2895092..2895370 (279 bp)
Type: Others
Protein ID: WP_013259394.1
Location: 2895471..2896055 (585 bp)
Type: Others
Protein ID: WP_013259395.1
Location: 2896215..2896526 (312 bp)
Type: Others
Protein ID: WP_013259396.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DEBA_RS129052887701..2888891-1191WP_187288633.1ParB N-terminal domain-containing protein-
DEBA_RS179002888897..2889241-345WP_013259387.1HNH endonuclease-
DEBA_RS129152889677..2889955+279WP_013259388.1DUF1778 domain-containing protein-
DEBA_RS129202889955..2890458+504WP_013259389.1GNAT family N-acetyltransferase-
DEBA_RS129252890549..2891676-1128WP_013259390.1Fic family protein-
DEBA_RS129302891932..2892216+285WP_013259391.1DUF1778 domain-containing proteinAntitoxin
DEBA_RS129352892213..2892713+501WP_013259392.1GNAT family N-acetyltransferaseToxin
DEBA_RS179052892843..2895092-2250WP_013259393.1primase-
DEBA_RS129452895092..2895370-279WP_013259394.1hypothetical protein-
DEBA_RS129502895471..2896055-585WP_013259395.1RNA polymerase subunit sigma-24-
DEBA_RS129552896215..2896526-312WP_013259396.1hypothetical protein-
DEBA_RS129602896783..2897121+339WP_013259397.1type II toxin-antitoxin system RelE/ParE family toxin-
DEBA_RS129652897105..2897440+336WP_013259398.1putative addiction module antidote protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2873610..290845434844


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(13-88)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18026.82 Da        Isoelectric Point: 7.3571

>T24864 WP_013259392.1 NC_014365:2892213-2892713 [Desulfarculus baarsii DSM 2075]
VICAPSLLAVEHDVALFLSGEPVLDDWLKRRALTNQASGASRTYVITDESRVIGYYALAAGAVTATEAPGKVRRNMPDPI
PVMVLGRLAVDQGWQGQGLGLDLLRDAILRTLQAAEIAGIRALLVHALHEQAARFYEHAGFRPSPLRPLAYFLTLADAQK
ALAFRE

Download         Length: 501 bp

>T24864 NC_014365:2892213-2892713 [Desulfarculus baarsii DSM 2075]
GTGATCTGTGCGCCGTCCCTTTTGGCAGTGGAGCACGATGTCGCTCTGTTCCTGTCCGGCGAGCCGGTCCTGGATGACTG
GCTCAAGCGCAGAGCGCTGACCAACCAGGCCAGTGGTGCATCGCGGACCTACGTCATCACCGACGAAAGCAGGGTGATCG
GCTATTACGCCTTGGCCGCCGGGGCGGTGACCGCAACCGAGGCCCCGGGCAAGGTGCGTCGCAACATGCCAGACCCCATC
CCTGTAATGGTGCTGGGGAGATTGGCAGTGGATCAGGGGTGGCAAGGTCAGGGGCTTGGCCTCGATCTCTTGCGGGATGC
CATACTTCGAACGCTTCAGGCGGCGGAGATTGCCGGTATCCGAGCCCTGCTCGTCCACGCGCTGCATGAACAAGCCGCAA
GATTCTACGAACATGCAGGGTTCCGTCCCTCTCCTCTCCGGCCTCTTGCGTACTTCCTGACACTTGCCGACGCGCAAAAA
GCCTTGGCTTTCAGAGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10384.68 Da        Isoelectric Point: 4.7719

>AT24864 WP_013259391.1 NC_014365:2891932-2892216 [Desulfarculus baarsii DSM 2075]
MPQTTSPSRSTNINIRVAPEQRNLIDQAASLSSKTRTDFILEAATKAAQDAILDQVLFPASAEQFEAFQKLLDSPPEENE
RLGALMARKPGWDK

Download         Length: 285 bp

>AT24864 NC_014365:2891932-2892216 [Desulfarculus baarsii DSM 2075]
ATGCCACAGACCACTTCCCCGAGTCGCAGCACGAATATCAATATTCGTGTGGCTCCCGAGCAGCGCAACCTGATCGACCA
AGCCGCCTCGCTTAGCAGCAAGACCAGGACGGACTTCATCCTGGAAGCGGCGACCAAGGCCGCGCAGGACGCCATCCTCG
ATCAGGTGTTGTTTCCCGCCTCAGCCGAACAGTTCGAGGCGTTCCAAAAGCTTCTGGACAGCCCGCCCGAAGAGAATGAA
CGCTTGGGAGCCCTCATGGCCCGTAAGCCAGGGTGGGATAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBE1QK60

Antitoxin

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Source
ID
Structure
AlphaFold DBE1QK59

References