Detailed information of TA system TA024864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 2891932..2892713
• Replicon: chromosome
• Accession: NC_014365
• Organism: Desulfarculus baarsii DSM 2075

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: E1QK60
• Locus tag: DEBA_RS12935
• Protein ID: WP_013259392.1
• Coordinates: 2892213..2892713 (+)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: E1QK59
• Locus tag: DEBA_RS12930
• Protein ID: WP_013259391.1
• Coordinates: 2891932..2892216 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEBA_RS12905	2887701..2888891	-	1191	WP_187288633.1	ParB N-terminal domain-containing protein	-
DEBA_RS17900	2888897..2889241	-	345	WP_013259387.1	HNH endonuclease	-
DEBA_RS12915	2889677..2889955	+	279	WP_013259388.1	DUF1778 domain-containing protein	-
DEBA_RS12920	2889955..2890458	+	504	WP_013259389.1	GNAT family N-acetyltransferase	-
DEBA_RS12925	2890549..2891676	-	1128	WP_013259390.1	Fic family protein	-
DEBA_RS12930	2891932..2892216	+	285	WP_013259391.1	DUF1778 domain-containing protein	Antitoxin
DEBA_RS12935	2892213..2892713	+	501	WP_013259392.1	GNAT family N-acetyltransferase	Toxin
DEBA_RS17905	2892843..2895092	-	2250	WP_013259393.1	primase	-
DEBA_RS12945	2895092..2895370	-	279	WP_013259394.1	hypothetical protein	-
DEBA_RS12950	2895471..2896055	-	585	WP_013259395.1	RNA polymerase subunit sigma-24	-
DEBA_RS12955	2896215..2896526	-	312	WP_013259396.1	hypothetical protein	-
DEBA_RS12960	2896783..2897121	+	339	WP_013259397.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DEBA_RS12965	2897105..2897440	+	336	WP_013259398.1	putative addiction module antidote protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2873610..2908454	34844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (41-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-88)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 18026.82 Da
• Isoelectric Point: 7.3571

>T24864 WP_013259392.1 NC_014365:2892213-2892713 [Desulfarculus baarsii DSM 2075]
VICAPSLLAVEHDVALFLSGEPVLDDWLKRRALTNQASGASRTYVITDESRVIGYYALAAGAVTATEAPGKVRRNMPDPI
PVMVLGRLAVDQGWQGQGLGLDLLRDAILRTLQAAEIAGIRALLVHALHEQAARFYEHAGFRPSPLRPLAYFLTLADAQK
ALAFRE

Nucleotide

• Length: 501 bp

>T24864 NC_014365:2892213-2892713 [Desulfarculus baarsii DSM 2075]
GTGATCTGTGCGCCGTCCCTTTTGGCAGTGGAGCACGATGTCGCTCTGTTCCTGTCCGGCGAGCCGGTCCTGGATGACTG
GCTCAAGCGCAGAGCGCTGACCAACCAGGCCAGTGGTGCATCGCGGACCTACGTCATCACCGACGAAAGCAGGGTGATCG
GCTATTACGCCTTGGCCGCCGGGGCGGTGACCGCAACCGAGGCCCCGGGCAAGGTGCGTCGCAACATGCCAGACCCCATC
CCTGTAATGGTGCTGGGGAGATTGGCAGTGGATCAGGGGTGGCAAGGTCAGGGGCTTGGCCTCGATCTCTTGCGGGATGC
CATACTTCGAACGCTTCAGGCGGCGGAGATTGCCGGTATCCGAGCCCTGCTCGTCCACGCGCTGCATGAACAAGCCGCAA
GATTCTACGAACATGCAGGGTTCCGTCCCTCTCCTCTCCGGCCTCTTGCGTACTTCCTGACACTTGCCGACGCGCAAAAA
GCCTTGGCTTTCAGAGAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10384.68 Da
• Isoelectric Point: 4.7719

>AT24864 WP_013259391.1 NC_014365:2891932-2892216 [Desulfarculus baarsii DSM 2075]
MPQTTSPSRSTNINIRVAPEQRNLIDQAASLSSKTRTDFILEAATKAAQDAILDQVLFPASAEQFEAFQKLLDSPPEENE
RLGALMARKPGWDK

Nucleotide

• Length: 285 bp

>AT24864 NC_014365:2891932-2892216 [Desulfarculus baarsii DSM 2075]
ATGCCACAGACCACTTCCCCGAGTCGCAGCACGAATATCAATATTCGTGTGGCTCCCGAGCAGCGCAACCTGATCGACCA
AGCCGCCTCGCTTAGCAGCAAGACCAGGACGGACTTCATCCTGGAAGCGGCGACCAAGGCCGCGCAGGACGCCATCCTCG
ATCAGGTGTTGTTTCCCGCCTCAGCCGAACAGTTCGAGGCGTTCCAAAAGCTTCTGGACAGCCCGCCCGAAGAGAATGAA
CGCTTGGGAGCCCTCATGGCCCGTAAGCCAGGGTGGGATAAGTGA

Structures

Toxin

• AlphaFold DB: E1QK60

Antitoxin

• AlphaFold DB: E1QK59