Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2358609..2359245 Replicon chromosome
Accession NZ_CP099364
Organism Citrobacter braakii strain RHB44-SE-C08

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag NFL11_RS11580 Protein ID WP_049259794.1
Coordinates 2358609..2358797 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFL11_RS11585 Protein ID WP_146053235.1
Coordinates 2358829..2359245 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL11_RS11560 (2355387) 2355387..2355617 - 231 WP_279268720.1 DUF2554 family protein -
NFL11_RS11565 (2355807) 2355807..2355932 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFL11_RS11570 (2355932) 2355932..2356942 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFL11_RS11575 (2356942) 2356942..2358345 - 1404 WP_016153156.1 cytochrome ubiquinol oxidase subunit I -
NFL11_RS11580 (2358609) 2358609..2358797 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
NFL11_RS11585 (2358829) 2358829..2359245 + 417 WP_146053235.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFL11_RS11590 (2359338) 2359338..2360747 + 1410 WP_103283798.1 PLP-dependent aminotransferase family protein -
NFL11_RS11595 (2361077) 2361077..2362222 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFL11_RS11600 (2362239) 2362239..2363255 + 1017 WP_016156582.1 ABC transporter ATP-binding protein -
NFL11_RS11605 (2363256) 2363256..2364200 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248632 WP_049259794.1 NZ_CP099364:2358609-2358797 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15080.33 Da        Isoelectric Point: 4.7119

>AT248632 WP_146053235.1 NZ_CP099364:2358829-2359245 [Citrobacter braakii]
MRYPVNLIPSVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References