Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 695836..696515 Replicon chromosome
Accession NZ_CP099364
Organism Citrobacter braakii strain RHB44-SE-C08

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag NFL11_RS03470 Protein ID WP_097724914.1
Coordinates 696174..696515 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID R8WMM2
Locus tag NFL11_RS03465 Protein ID WP_006812013.1
Coordinates 695836..696153 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFL11_RS03420 (691275) 691275..692093 + 819 WP_096996569.1 DUF932 domain-containing protein -
NFL11_RS03425 (692310) 692310..693011 + 702 WP_001548933.1 WYL domain-containing protein -
NFL11_RS03430 (693052) 693052..693288 + 237 WP_001144031.1 protein YpjK -
NFL11_RS03435 (693288) 693288..693731 + 444 WP_001547764.1 lipoprotein YafY -
NFL11_RS03440 (693755) 693755..694222 + 468 WP_001547765.1 protein YkfB -
NFL11_RS03445 (694299) 694299..694538 + 240 WP_000194654.1 DUF905 family protein -
NFL11_RS03450 (694636) 694636..695094 + 459 WP_000211838.1 antirestriction protein -
NFL11_RS03455 (695110) 695110..695586 + 477 WP_000811693.1 RadC family protein -
NFL11_RS03460 (695595) 695595..695816 + 222 WP_000691995.1 DUF987 domain-containing protein -
NFL11_RS03465 (695836) 695836..696153 + 318 WP_006812013.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NFL11_RS03470 (696174) 696174..696515 + 342 WP_097724914.1 TA system toxin CbtA family protein Toxin
NFL11_RS03475 (696631) 696631..697464 + 834 WP_046495848.1 DUF4942 domain-containing protein -
NFL11_RS03485 (697768) 697768..698274 + 507 WP_016157505.1 G/U mismatch-specific DNA glycosylase -
NFL11_RS03490 (698320) 698320..700164 - 1845 WP_016154549.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 652328..696515 44187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12959.00 Da        Isoelectric Point: 10.2764

>T248630 WP_097724914.1 NZ_CP099364:696174-696515 [Citrobacter braakii]
MKTLPATTQRAAKPCLAPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11874.45 Da        Isoelectric Point: 7.0166

>AT248630 WP_006812013.1 NZ_CP099364:695836-696153 [Citrobacter braakii]
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB R8WMM2

References