Detailed information of TA system TA024863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2889677..2890458
• Replicon: chromosome
• Accession: NC_014365
• Organism: Desulfarculus baarsii DSM 2075

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: E1QK57
• Locus tag: DEBA_RS12920
• Protein ID: WP_013259389.1
• Coordinates: 2889955..2890458 (+)
• Length: 168 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: E1QK56
• Locus tag: DEBA_RS12915
• Protein ID: WP_013259388.1
• Coordinates: 2889677..2889955 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEBA_RS12885	2885151..2885606	-	456	WP_013259382.1	phage terminase small subunit P27 family	-
DEBA_RS12890	2885662..2885916	+	255	WP_013259383.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DEBA_RS12895	2885913..2886284	+	372	WP_013259384.1	helix-turn-helix domain-containing protein	-
DEBA_RS12900	2886293..2887711	-	1419	WP_013259385.1	site-specific DNA-methyltransferase	-
DEBA_RS12905	2887701..2888891	-	1191	WP_187288633.1	ParB N-terminal domain-containing protein	-
DEBA_RS17900	2888897..2889241	-	345	WP_013259387.1	HNH endonuclease	-
DEBA_RS12915	2889677..2889955	+	279	WP_013259388.1	DUF1778 domain-containing protein	Antitoxin
DEBA_RS12920	2889955..2890458	+	504	WP_013259389.1	GNAT family N-acetyltransferase	Toxin
DEBA_RS12925	2890549..2891676	-	1128	WP_013259390.1	Fic family protein	-
DEBA_RS12930	2891932..2892216	+	285	WP_013259391.1	DUF1778 domain-containing protein	-
DEBA_RS12935	2892213..2892713	+	501	WP_013259392.1	GNAT family N-acetyltransferase	-
DEBA_RS17905	2892843..2895092	-	2250	WP_013259393.1	primase	-
DEBA_RS12945	2895092..2895370	-	279	WP_013259394.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2873610..2908454	34844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-137)

Antitoxin

• Vibrio phage ICP1, Orf50 (11-85)

Sequences

Toxin

Protein

• Length: 168 a.a.
• Molecular weight: 18619.37 Da
• Isoelectric Point: 8.7103

>T24863 WP_013259389.1 NC_014365:2889955-2890458 [Desulfarculus baarsii DSM 2075]
MGGRFGPVHKLTAADEAGDFDCGRQELNLFLQRYALVNQRANSAQTYVSCVDDAVVGYYSLCVGSVGFDEAPHRVQKGLA
RHRVPVMLLARLGVDQRFQRLGLGRALLKDAILRTLQAADIAGIRALLAHAKDEHARQWYLSWDFEPSPTDPFHLFLLIK
DMRAAGR

Nucleotide

• Length: 504 bp

>T24863 NC_014365:2889955-2890458 [Desulfarculus baarsii DSM 2075]
ATGGGCGGTCGGTTTGGTCCGGTCCACAAGCTAACGGCAGCGGACGAGGCAGGGGATTTCGATTGCGGTCGGCAGGAACT
GAATCTGTTTTTGCAACGCTATGCCCTTGTCAACCAGAGAGCCAACAGCGCCCAGACCTATGTGTCCTGCGTGGACGATG
CTGTCGTCGGCTACTACAGCCTCTGTGTGGGTAGCGTCGGCTTTGATGAAGCGCCCCATCGGGTGCAAAAAGGGCTTGCC
AGACACCGCGTACCTGTCATGCTGCTGGCTCGCCTTGGCGTGGATCAGCGGTTTCAGCGCCTTGGGTTGGGCCGGGCCCT
GCTCAAAGACGCCATCCTGCGCACCTTGCAGGCGGCGGATATCGCCGGCATCCGCGCCTTACTGGCCCACGCCAAGGACG
AACACGCCAGGCAGTGGTATTTATCCTGGGATTTCGAGCCCAGCCCAACGGACCCTTTTCACCTGTTTTTGCTCATCAAG
GACATGCGTGCGGCTGGAAGGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10337.92 Da
• Isoelectric Point: 9.9470

>AT24863 WP_013259388.1 NC_014365:2889677-2889955 [Desulfarculus baarsii DSM 2075]
MSPTTQTKTERIDVRLSPSSKALLQEAAKATHKNVSEFILEAGIVAANQALAERRIFLLDEARWKEFQEVLDRPVQKKPR
LGKLLNDPGVLD

Nucleotide

• Length: 279 bp

>AT24863 NC_014365:2889677-2889955 [Desulfarculus baarsii DSM 2075]
ATGTCGCCCACCACTCAGACGAAGACGGAACGAATCGACGTCCGGCTCAGTCCCTCATCGAAGGCGCTGCTGCAGGAAGC
GGCCAAGGCGACGCATAAAAACGTCAGCGAGTTCATTTTGGAGGCGGGGATTGTCGCCGCCAATCAGGCCTTGGCTGAAC
GACGGATATTCCTGCTGGACGAAGCTCGGTGGAAAGAGTTTCAGGAGGTACTGGATCGTCCTGTCCAGAAGAAGCCTCGC
CTGGGCAAACTGCTGAACGATCCTGGCGTTCTTGACTGA

Structures

Toxin

• AlphaFold DB: E1QK57

Antitoxin

• AlphaFold DB: E1QK56