Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 67079..67680 Replicon plasmid unnamed2
Accession NZ_CP099360
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag NFJ18_RS23810 Protein ID WP_001216045.1
Coordinates 67079..67459 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NFJ18_RS23815 Protein ID WP_181465529.1
Coordinates 67459..67680 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS23780 (NFJ18_23740) 62179..62298 - 120 WP_071594056.1 ash family protein -
NFJ18_RS23785 (NFJ18_23745) 62520..63962 - 1443 WP_236522756.1 terminase -
NFJ18_RS23790 (NFJ18_23750) 64004..65197 - 1194 WP_096321055.1 terminase -
NFJ18_RS23795 (NFJ18_23755) 65283..65735 - 453 WP_001326849.1 late promoter-activating protein -
NFJ18_RS23800 (NFJ18_23760) 65824..66867 - 1044 WP_069187067.1 DUF968 domain-containing protein -
NFJ18_RS23805 (NFJ18_23765) 66895..67074 - 180 WP_001339207.1 hypothetical protein -
NFJ18_RS23810 (NFJ18_23770) 67079..67459 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NFJ18_RS23815 (NFJ18_23775) 67459..67680 - 222 WP_181465529.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NFJ18_RS23820 (NFJ18_23780) 67863..69419 + 1557 WP_181465530.1 type I restriction-modification system subunit M -
NFJ18_RS23825 (NFJ18_23785) 69416..70696 + 1281 WP_113449347.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94718 94718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T248628 WP_001216045.1 NZ_CP099360:c67459-67079 [Escherichia fergusonii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8103.07 Da        Isoelectric Point: 4.7708

>AT248628 WP_181465529.1 NZ_CP099360:c67680-67459 [Escherichia fergusonii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDALDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure

References