Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid unnamed1
Accession NZ_CP099359
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag NFJ18_RS22830 Protein ID WP_001384452.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag NFJ18_RS22825 Protein ID WP_000079928.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS22815 (46) 46..1077 + 1032 WP_000907875.1 plasmid replication initiator RepA -
NFJ18_RS22820 (1773) 1773..1931 + 159 WP_000841008.1 hypothetical protein -
NFJ18_RS22825 (1986) 1986..2255 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NFJ18_RS22830 (2255) 2255..2533 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
NFJ18_RS22835 (2573) 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
NFJ18_RS22840 (3658) 3658..3783 - 126 Protein_5 MerR family transcriptional regulator -
NFJ18_RS22845 (3778) 3778..4392 + 615 Protein_6 helix-turn-helix domain-containing protein -
NFJ18_RS22850 (4401) 4401..5261 + 861 WP_000493383.1 EamA family transporter -
NFJ18_RS22855 (5293) 5293..6492 - 1200 WP_181465503.1 tetracycline efflux MFS transporter Tet(A) -
NFJ18_RS22860 (6598) 6598..7248 + 651 WP_181465513.1 tetracycline resistance transcriptional repressor TetR(A) -
NFJ18_RS22865 (7280) 7280..7522 - 243 WP_000844627.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / aadA2 / cmlA1 / ant(3'')-Ia / sul3 - 1..116881 116881
- flank IS/Tn tet(A) - 5293..9506 4213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T248623 WP_001384452.1 NZ_CP099359:2255-2533 [Escherichia fergusonii]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT248623 WP_000079928.1 NZ_CP099359:1986-2255 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References