Detailed information of TA system TA024862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 2885662..2886284
• Replicon: chromosome
• Accession: NC_014365
• Organism: Desulfarculus baarsii DSM 2075

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E1QK51
• Locus tag: DEBA_RS12890
• Protein ID: WP_013259383.1
• Coordinates: 2885662..2885916 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DEBA_RS12895
• Protein ID: WP_013259384.1
• Coordinates: 2885913..2886284 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEBA_RS12870	2881468..2882205	-	738	WP_013259379.1	Clp protease ClpP	-
DEBA_RS12875	2882195..2883451	-	1257	WP_013259380.1	phage portal protein	-
DEBA_RS12880	2883448..2885148	-	1701	WP_013259381.1	terminase large subunit	-
DEBA_RS12885	2885151..2885606	-	456	WP_013259382.1	phage terminase small subunit P27 family	-
DEBA_RS12890	2885662..2885916	+	255	WP_013259383.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DEBA_RS12895	2885913..2886284	+	372	WP_013259384.1	helix-turn-helix domain-containing protein	Antitoxin
DEBA_RS12900	2886293..2887711	-	1419	WP_013259385.1	site-specific DNA-methyltransferase	-
DEBA_RS12905	2887701..2888891	-	1191	WP_187288633.1	ParB N-terminal domain-containing protein	-
DEBA_RS17900	2888897..2889241	-	345	WP_013259387.1	HNH endonuclease	-
DEBA_RS12915	2889677..2889955	+	279	WP_013259388.1	DUF1778 domain-containing protein	-
DEBA_RS12920	2889955..2890458	+	504	WP_013259389.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2873610..2908454	34844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• Cro/C1-type helix-turn-helix domain (68-122)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9699.38 Da
• Isoelectric Point: 10.7948

>T24862 WP_013259383.1 NC_014365:2885662-2885916 [Desulfarculus baarsii DSM 2075]
MYALRFSTTALKALRKAPADVVGRIRAKLDELTRDPFTAANVKKLTSHPGYRLRVGDWRVIYLVQKEEVVIQIVDIGQRK
EVYR

Nucleotide

• Length: 255 bp

>T24862 NC_014365:2885662-2885916 [Desulfarculus baarsii DSM 2075]
ATGTATGCGCTGCGCTTTTCCACAACCGCGTTGAAGGCCCTCAGGAAAGCGCCCGCTGATGTGGTCGGGCGCATCCGGGC
GAAGCTGGATGAACTGACGCGAGATCCCTTCACGGCCGCCAACGTCAAAAAGCTCACCAGCCATCCGGGATATCGGTTGC
GCGTCGGCGACTGGCGGGTGATCTACCTGGTCCAAAAGGAAGAGGTCGTCATCCAGATAGTGGACATCGGACAGCGCAAA
GAGGTGTATCGATGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13815.81 Da
• Isoelectric Point: 4.8518

>AT24862 WP_013259384.1 NC_014365:2885913-2886284 [Desulfarculus baarsii DSM 2075]
MSVQILEHEGRPAFALMPIEEYERLVAALEDAHDAATIEEFYRRLVSGEEETFPAEVVDRLLAGEHPVRVLRSHRGMTLQ
QVADACGVTNSHISQIEKGKRSMSTELLKKMAEALRVDAEMLL

Nucleotide

• Length: 372 bp

>AT24862 NC_014365:2885913-2886284 [Desulfarculus baarsii DSM 2075]
ATGAGCGTCCAGATTCTCGAGCACGAAGGACGGCCGGCGTTCGCGTTGATGCCGATCGAAGAATACGAACGTCTTGTGGC
AGCCCTCGAGGATGCGCACGACGCCGCGACCATCGAGGAGTTCTATCGTCGGCTTGTCTCCGGCGAAGAGGAAACCTTTC
CGGCGGAAGTCGTCGACCGGCTGCTGGCTGGAGAGCATCCTGTCCGGGTGCTGCGCTCCCATCGGGGCATGACCCTGCAG
CAGGTCGCGGATGCCTGCGGAGTGACCAACTCCCACATCTCCCAGATCGAAAAGGGCAAGCGCTCCATGTCCACGGAGTT
GCTGAAGAAGATGGCCGAGGCGCTCCGCGTGGACGCGGAGATGTTGTTGTAA

Structures

Toxin

• AlphaFold DB: E1QK51