Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3559728..3560382 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NFJ18_RS17260 Protein ID WP_000244781.1
Coordinates 3559728..3560135 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NFJ18_RS17265 Protein ID WP_000354046.1
Coordinates 3560116..3560382 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS17240 (3555685) 3555685..3557418 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
NFJ18_RS17245 (3557424) 3557424..3558134 - 711 WP_104917537.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ18_RS17250 (3558159) 3558159..3559055 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
NFJ18_RS17255 (3559167) 3559167..3559688 + 522 WP_001055874.1 flavodoxin FldB -
NFJ18_RS17260 (3559728) 3559728..3560135 - 408 WP_000244781.1 protein YgfX Toxin
NFJ18_RS17265 (3560116) 3560116..3560382 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NFJ18_RS17270 (3560634) 3560634..3561614 + 981 WP_181202810.1 tRNA-modifying protein YgfZ -
NFJ18_RS17275 (3561691) 3561691..3562350 - 660 WP_000250283.1 hemolysin III family protein -
NFJ18_RS17280 (3562514) 3562514..3562825 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
NFJ18_RS17285 (3562870) 3562870..3564303 + 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
NFJ18_RS17290 (3564351) 3564351..3565244 - 894 WP_000819362.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T248618 WP_000244781.1 NZ_CP099358:c3560135-3559728 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT248618 WP_000354046.1 NZ_CP099358:c3560382-3560116 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References