Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3292820..3293439 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFJ18_RS16035 Protein ID WP_001280991.1
Coordinates 3293221..3293439 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag NFJ18_RS16030 Protein ID WP_000344803.1
Coordinates 3292820..3293194 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS16020 (3287952) 3287952..3289145 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ18_RS16025 (3289168) 3289168..3292317 + 3150 WP_001132493.1 efflux RND transporter permease AcrB -
NFJ18_RS16030 (3292820) 3292820..3293194 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
NFJ18_RS16035 (3293221) 3293221..3293439 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NFJ18_RS16040 (3293934) 3293934..3294404 + 471 WP_002431406.1 YlaC family protein -
NFJ18_RS16045 (3294543) 3294543..3296093 + 1551 WP_181202748.1 EAL domain-containing protein -
NFJ18_RS16050 (3296135) 3296135..3296488 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NFJ18_RS16060 (3296867) 3296867..3297178 + 312 WP_000409907.1 MGMT family protein -
NFJ18_RS16065 (3297209) 3297209..3297781 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248617 WP_001280991.1 NZ_CP099358:3293221-3293439 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT248617 WP_000344803.1 NZ_CP099358:3292820-3293194 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References