Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1303754..1304379 Replicon chromosome
Accession NZ_CP099358
Organism Escherichia fergusonii strain RHB02-E1-C03

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NFJ18_RS06315 Protein ID WP_000911329.1
Coordinates 1303981..1304379 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NFJ18_RS06310 Protein ID WP_000450524.1
Coordinates 1303754..1303981 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ18_RS06285 (1299556) 1299556..1300026 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
NFJ18_RS06290 (1300026) 1300026..1300598 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
NFJ18_RS06295 (1300745) 1300745..1301623 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
NFJ18_RS06300 (1301640) 1301640..1302674 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
NFJ18_RS06305 (1302886) 1302886..1303599 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NFJ18_RS06310 (1303754) 1303754..1303981 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NFJ18_RS06315 (1303981) 1303981..1304379 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NFJ18_RS06320 (1304526) 1304526..1305389 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NFJ18_RS06325 (1305404) 1305404..1307419 + 2016 WP_181203253.1 tRNA cytosine(34) acetyltransferase TmcA -
NFJ18_RS06330 (1307493) 1307493..1308194 + 702 WP_105288162.1 esterase -
NFJ18_RS06335 (1308289) 1308289..1308489 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T248610 WP_000911329.1 NZ_CP099358:1303981-1304379 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT248610 WP_000450524.1 NZ_CP099358:1303754-1303981 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References