Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 65603..66204 Replicon plasmid unnamed1
Accession NZ_CP099352
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag NFJ26_RS22115 Protein ID WP_001216034.1
Coordinates 65824..66204 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag NFJ26_RS22110 Protein ID WP_001190712.1
Coordinates 65603..65824 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS22100 (NFJ26_22005) 62632..63867 - 1236 WP_032175094.1 restriction endonuclease subunit S -
NFJ26_RS22105 (NFJ26_22010) 63864..65420 - 1557 WP_001568002.1 type I restriction-modification system subunit M -
NFJ26_RS22110 (NFJ26_22015) 65603..65824 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NFJ26_RS22115 (NFJ26_22020) 65824..66204 + 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NFJ26_RS22120 (NFJ26_22025) 66209..66388 + 180 WP_001446091.1 hypothetical protein -
NFJ26_RS22125 (NFJ26_22030) 66416..67459 + 1044 WP_000648817.1 DUF968 domain-containing protein -
NFJ26_RS22130 (NFJ26_22035) 67548..68000 + 453 WP_062871772.1 hypothetical protein -
NFJ26_RS22135 (NFJ26_22040) 68086..69279 + 1194 WP_016240561.1 hypothetical protein -
NFJ26_RS22140 (NFJ26_22045) 69321..70763 + 1443 WP_227453992.1 terminase -
NFJ26_RS22145 (NFJ26_22050) 70977..71078 + 102 Protein_77 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..116771 116771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T248604 WP_001216034.1 NZ_CP099352:65824-66204 [Escherichia marmotae]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT248604 WP_001190712.1 NZ_CP099352:65603-65824 [Escherichia marmotae]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References