Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3606087..3606738 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag NFJ26_RS17160 Protein ID WP_000244789.1
Coordinates 3606087..3606491 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag NFJ26_RS17165 Protein ID WP_000354045.1
Coordinates 3606472..3606738 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS17140 (3602051) 3602051..3603784 - 1734 WP_000813173.1 single-stranded-DNA-specific exonuclease RecJ -
NFJ26_RS17145 (3603790) 3603790..3604500 - 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ26_RS17150 (3604525) 3604525..3605421 - 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
NFJ26_RS17155 (3605532) 3605532..3606053 + 522 WP_001055874.1 flavodoxin FldB -
NFJ26_RS17160 (3606087) 3606087..3606491 - 405 WP_000244789.1 protein YgfX Toxin
NFJ26_RS17165 (3606472) 3606472..3606738 - 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
NFJ26_RS17170 (3606991) 3606991..3607971 + 981 WP_000886070.1 tRNA-modifying protein YgfZ -
NFJ26_RS17175 (3608118) 3608118..3608777 - 660 WP_000250293.1 hemolysin III family protein -
NFJ26_RS17180 (3608940) 3608940..3609251 - 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
NFJ26_RS17185 (3609296) 3609296..3610729 + 1434 WP_010378607.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T248603 WP_000244789.1 NZ_CP099351:c3606491-3606087 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT248603 WP_000354045.1 NZ_CP099351:c3606738-3606472 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References