Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2323052..2323690 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NFJ26_RS10960 Protein ID WP_000813795.1
Coordinates 2323514..2323690 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ26_RS10955 Protein ID WP_077627724.1
Coordinates 2323052..2323468 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS10935 (2318207) 2318207..2319148 - 942 WP_001251301.1 ABC transporter permease -
NFJ26_RS10940 (2319149) 2319149..2320162 - 1014 WP_000220424.1 ABC transporter ATP-binding protein -
NFJ26_RS10945 (2320180) 2320180..2321325 - 1146 WP_000047463.1 ABC transporter substrate-binding protein -
NFJ26_RS10950 (2321564) 2321564..2322973 - 1410 WP_000760662.1 PLP-dependent aminotransferase family protein -
NFJ26_RS10955 (2323052) 2323052..2323468 - 417 WP_077627724.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NFJ26_RS10960 (2323514) 2323514..2323690 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NFJ26_RS10965 (2323912) 2323912..2324142 + 231 WP_000494240.1 DUF2554 family protein -
NFJ26_RS10970 (2324236) 2324236..2326197 - 1962 WP_010376311.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NFJ26_RS10975 (2326270) 2326270..2326806 - 537 WP_000429073.1 XRE family transcriptional regulator -
NFJ26_RS10980 (2326898) 2326898..2328070 + 1173 WP_001236306.1 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T248601 WP_000813795.1 NZ_CP099351:c2323690-2323514 [Escherichia marmotae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15250.62 Da        Isoelectric Point: 4.5908

>AT248601 WP_077627724.1 NZ_CP099351:c2323468-2323052 [Escherichia marmotae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References