Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2848520..2849316 Replicon chromosome
Accession NC_014365
Organism Desulfarculus baarsii DSM 2075

Toxin (Protein)


Gene name tacT Uniprot ID E1QK21
Locus tag DEBA_RS12750 Protein ID WP_013259353.1
Coordinates 2848798..2849316 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID E1QK20
Locus tag DEBA_RS12745 Protein ID WP_013259352.1
Coordinates 2848520..2848798 (+) Length 93 a.a.

Genomic Context

DEBA_RS12720DEBA_RS12730DEBA_RS12735DEBA_RS12745DEBA_RS12750DEBA_RS12755DEBA_RS12725DEBA_RS12740DEBA_RS17880DEBA_RS12765DEBA_RS12770DEBA_RS12775
Location: 2844876..2845070 (195 bp)
Type: Others
Protein ID: WP_013259345.1
Location: 2845856..2846197 (342 bp)
Type: Others
Protein ID: WP_043814504.1
Location: 2846457..2846708 (252 bp)
Type: Others
Protein ID: Protein_2562
Location: 2848520..2848798 (279 bp)
Type: Antitoxin
Protein ID: WP_013259352.1
Location: 2848798..2849316 (519 bp)
Type: Toxin
Protein ID: WP_013259353.1
Location: 2849450..2849734 (285 bp)
Type: Others
Protein ID: WP_013259354.1
Location: 2845079..2845537 (459 bp)
Type: Others
Protein ID: WP_013259346.1
Location: 2846724..2847911 (1188 bp)
Type: Others
Protein ID: WP_013259350.1
Location: 2849838..2852072 (2235 bp)
Type: Others
Protein ID: WP_013259355.1
Location: 2852072..2852350 (279 bp)
Type: Others
Protein ID: WP_013259356.1
Location: 2852455..2853039 (585 bp)
Type: Others
Protein ID: WP_013259357.1
Location: 2853199..2853519 (321 bp)
Type: Others
Protein ID: WP_013259358.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DEBA_RS127202844876..2845070+195WP_013259345.1hypothetical protein-
DEBA_RS127252845079..2845537-459WP_013259346.1phage terminase small subunit P27 family-
DEBA_RS127302845856..2846197+342WP_043814504.1helix-turn-helix transcriptional regulator-
DEBA_RS127352846457..2846708+252Protein_2562helix-turn-helix transcriptional regulator-
DEBA_RS127402846724..2847911-1188WP_013259350.1DNA modification methylase-
DEBA_RS127452848520..2848798+279WP_013259352.1DUF1778 domain-containing proteinAntitoxin
DEBA_RS127502848798..2849316+519WP_013259353.1GNAT family N-acetyltransferaseToxin
DEBA_RS127552849450..2849734+285WP_013259354.1DUF1778 domain-containing protein-
DEBA_RS178802849838..2852072-2235WP_013259355.1primase-
DEBA_RS127652852072..2852350-279WP_013259356.1hypothetical protein-
DEBA_RS127702852455..2853039-585WP_013259357.1RNA polymerase subunit sigma-24-
DEBA_RS127752853199..2853519-321WP_013259358.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--2833759..285351919760


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-147)

Antitoxin

Vibrio phage ICP1, Orf50

(11-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19155.94 Da        Isoelectric Point: 7.7708

>T24860 WP_013259353.1 NC_014365:2848798-2849316 [Desulfarculus baarsii DSM 2075]
MGGRFGPVHKLTAADEAGDFDCGQQELNLFLQRYALVNQRANSAQTYVSCVDDAVVGYYSLCVGSVGFDEAPHRVVKGLA
RHRVPVMLLARLGVDQRFQRQGLGRALLKDAILRTMQAADIAGIRALLAHAKDEHARQWYLSWDFEPSPTDPFHLFLLIK
DMRAAGRQDCLT

Download         Length: 519 bp

>T24860 NC_014365:2848798-2849316 [Desulfarculus baarsii DSM 2075]
ATGGGTGGTCGGTTTGGTCCGGTCCACAAGCTTACGGCAGCGGATGAGGCAGGGGATTTCGATTGCGGCCAGCAGGAACT
GAATCTGTTCTTGCAGCGCTATGCCCTTGTCAACCAGAGAGCCAACAGCGCCCAGACGTATGTGTCCTGCGTGGACGACG
CTGTCGTCGGCTACTACAGCCTCTGTGTGGGCAGCGTCGGCTTTGATGAAGCGCCCCATCGGGTGGTAAAAGGGCTTGCC
AGACATCGAGTCCCTGTCATGCTGCTGGCCCGCCTTGGCGTGGATCAGAGGTTTCAGCGTCAGGGGTTGGGCCGGGCCCT
GCTCAAGGACGCCATCCTGCGCACCATGCAGGCGGCGGATATCGCCGGCATCCGTGCATTACTGGCGCACGCCAAGGACG
AGCATGCCCGGCAGTGGTATCTCTCCTGGGACTTCGAGCCCAGCCCCACGGACCCTTTTCACCTGTTTTTGCTCATCAAG
GACATGCGTGCGGCGGGAAGGCAGGACTGCCTCACCTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10353.92 Da        Isoelectric Point: 9.9470

>AT24860 WP_013259352.1 NC_014365:2848520-2848798 [Desulfarculus baarsii DSM 2075]
MSPTTQTKTERIDVRLSPSSKALLQEAAKASHKNVSEFILEAGIVAANQALADRRLFLLDEARWKEFQEVLDRPVQKKPR
LSKLLNEPGVLD

Download         Length: 279 bp

>AT24860 NC_014365:2848520-2848798 [Desulfarculus baarsii DSM 2075]
ATGTCGCCCACCACTCAGACGAAAACGGAACGGATCGACGTCCGGCTCAGTCCCTCATCGAAGGCGCTGTTGCAGGAAGC
GGCCAAGGCGTCTCATAAAAACGTCAGCGAGTTTATTTTGGAGGCGGGGATTGTCGCCGCCAATCAGGCCTTGGCTGACC
GACGGCTGTTCCTGCTGGACGAAGCTCGGTGGAAAGAGTTTCAGGAGGTACTGGATCGTCCTGTCCAGAAGAAGCCTCGC
CTGAGCAAACTGCTGAACGAGCCTGGCGTTCTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBE1QK21

Antitoxin

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Source
ID
Structure
AlphaFold DBE1QK20

References