Detailed information of TA system TA024860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2848520..2849316
• Replicon: chromosome
• Accession: NC_014365
• Organism: Desulfarculus baarsii DSM 2075

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: E1QK21
• Locus tag: DEBA_RS12750
• Protein ID: WP_013259353.1
• Coordinates: 2848798..2849316 (+)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: E1QK20
• Locus tag: DEBA_RS12745
• Protein ID: WP_013259352.1
• Coordinates: 2848520..2848798 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEBA_RS12720	2844876..2845070	+	195	WP_013259345.1	hypothetical protein	-
DEBA_RS12725	2845079..2845537	-	459	WP_013259346.1	phage terminase small subunit P27 family	-
DEBA_RS12730	2845856..2846197	+	342	WP_043814504.1	helix-turn-helix transcriptional regulator	-
DEBA_RS12735	2846457..2846708	+	252	Protein_2562	helix-turn-helix transcriptional regulator	-
DEBA_RS12740	2846724..2847911	-	1188	WP_013259350.1	DNA modification methylase	-
DEBA_RS12745	2848520..2848798	+	279	WP_013259352.1	DUF1778 domain-containing protein	Antitoxin
DEBA_RS12750	2848798..2849316	+	519	WP_013259353.1	GNAT family N-acetyltransferase	Toxin
DEBA_RS12755	2849450..2849734	+	285	WP_013259354.1	DUF1778 domain-containing protein	-
DEBA_RS17880	2849838..2852072	-	2235	WP_013259355.1	primase	-
DEBA_RS12765	2852072..2852350	-	279	WP_013259356.1	hypothetical protein	-
DEBA_RS12770	2852455..2853039	-	585	WP_013259357.1	RNA polymerase subunit sigma-24	-
DEBA_RS12775	2853199..2853519	-	321	WP_013259358.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2833759..2853519	19760

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (11-86)

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19155.94 Da
• Isoelectric Point: 7.7708

>T24860 WP_013259353.1 NC_014365:2848798-2849316 [Desulfarculus baarsii DSM 2075]
MGGRFGPVHKLTAADEAGDFDCGQQELNLFLQRYALVNQRANSAQTYVSCVDDAVVGYYSLCVGSVGFDEAPHRVVKGLA
RHRVPVMLLARLGVDQRFQRQGLGRALLKDAILRTMQAADIAGIRALLAHAKDEHARQWYLSWDFEPSPTDPFHLFLLIK
DMRAAGRQDCLT

Nucleotide

• Length: 519 bp

>T24860 NC_014365:2848798-2849316 [Desulfarculus baarsii DSM 2075]
ATGGGTGGTCGGTTTGGTCCGGTCCACAAGCTTACGGCAGCGGATGAGGCAGGGGATTTCGATTGCGGCCAGCAGGAACT
GAATCTGTTCTTGCAGCGCTATGCCCTTGTCAACCAGAGAGCCAACAGCGCCCAGACGTATGTGTCCTGCGTGGACGACG
CTGTCGTCGGCTACTACAGCCTCTGTGTGGGCAGCGTCGGCTTTGATGAAGCGCCCCATCGGGTGGTAAAAGGGCTTGCC
AGACATCGAGTCCCTGTCATGCTGCTGGCCCGCCTTGGCGTGGATCAGAGGTTTCAGCGTCAGGGGTTGGGCCGGGCCCT
GCTCAAGGACGCCATCCTGCGCACCATGCAGGCGGCGGATATCGCCGGCATCCGTGCATTACTGGCGCACGCCAAGGACG
AGCATGCCCGGCAGTGGTATCTCTCCTGGGACTTCGAGCCCAGCCCCACGGACCCTTTTCACCTGTTTTTGCTCATCAAG
GACATGCGTGCGGCGGGAAGGCAGGACTGCCTCACCTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10353.92 Da
• Isoelectric Point: 9.9470

>AT24860 WP_013259352.1 NC_014365:2848520-2848798 [Desulfarculus baarsii DSM 2075]
MSPTTQTKTERIDVRLSPSSKALLQEAAKASHKNVSEFILEAGIVAANQALADRRLFLLDEARWKEFQEVLDRPVQKKPR
LSKLLNEPGVLD

Nucleotide

• Length: 279 bp

>AT24860 NC_014365:2848520-2848798 [Desulfarculus baarsii DSM 2075]
ATGTCGCCCACCACTCAGACGAAAACGGAACGGATCGACGTCCGGCTCAGTCCCTCATCGAAGGCGCTGTTGCAGGAAGC
GGCCAAGGCGTCTCATAAAAACGTCAGCGAGTTTATTTTGGAGGCGGGGATTGTCGCCGCCAATCAGGCCTTGGCTGACC
GACGGCTGTTCCTGCTGGACGAAGCTCGGTGGAAAGAGTTTCAGGAGGTACTGGATCGTCCTGTCCAGAAGAAGCCTCGC
CTGAGCAAACTGCTGAACGAGCCTGGCGTTCTTGACTGA

Structures

Toxin

• AlphaFold DB: E1QK21

Antitoxin

• AlphaFold DB: E1QK20