Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2215132..2216720 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name hipA Uniprot ID A0A7U9DLY5
Locus tag NFJ26_RS10550 Protein ID WP_001125477.1
Coordinates 2215398..2216720 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NFJ26_RS10545 Protein ID WP_001516368.1
Coordinates 2215132..2215398 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS10530 (2211808) 2211808..2212722 + 915 WP_001516366.1 bestrophin family protein -
NFJ26_RS10535 (2212726) 2212726..2213484 - 759 WP_000796279.1 trans-aconitate 2-methyltransferase -
NFJ26_RS10540 (2213912) 2213912..2214868 + 957 WP_000197006.1 hypothetical protein -
NFJ26_RS10545 (2215132) 2215132..2215398 + 267 WP_001516368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NFJ26_RS10550 (2215398) 2215398..2216720 + 1323 WP_001125477.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NFJ26_RS10555 (2217092) 2217092..2218408 + 1317 WP_058672600.1 site-specific integrase -
NFJ26_RS10560 (2218440) 2218440..2219948 + 1509 WP_227643223.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2213912..2246854 32942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49556.21 Da        Isoelectric Point: 8.5841

>T248599 WP_001125477.1 NZ_CP099351:2215398-2216720 [Escherichia marmotae]
MPKLVTWMNNQRVGELTKLTNGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPEDETVTRPIMVWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRMGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKEFGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGSTDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGRKTEIDKIYPRHFLATAKALKFPEVQMHEILSDFARMIP
AALDNVKASLPADFPENVLTAIETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10034.37 Da        Isoelectric Point: 4.5668

>AT248599 WP_001516368.1 NZ_CP099351:2215132-2215398 [Escherichia marmotae]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLNLSMTLCDTKNDSPES
TDQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DLY5

Antitoxin

Source ID Structure

References