Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1146986..1147604 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFJ26_RS05345 Protein ID WP_001280991.1
Coordinates 1146986..1147204 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag NFJ26_RS05350 Protein ID WP_000344801.1
Coordinates 1147209..1147604 (-) Length 132 a.a.

Genomic Context


NFJ26_RS05310NFJ26_RS05325NFJ26_RS05315NFJ26_RS05330NFJ26_RS05335NFJ26_RS05340NFJ26_RS05345NFJ26_RS05350NFJ26_RS05355NFJ26_RS05360
Location: 1142280..1142852 (573 bp)
Type: Others
Protein ID: WP_000779817.1
Location: 1143574..1143927 (354 bp)
Type: Others
Protein ID: WP_000878149.1
Location: 1142883..1143194 (312 bp)
Type: Others
Protein ID: WP_000409903.1
Location: 1143964..1145514 (1551 bp)
Type: Others
Protein ID: WP_001515896.1
Location: 1145678..1146148 (471 bp)
Type: Others
Protein ID: WP_010379081.1
Location: 1146263..1146814 (552 bp)
Type: Others
Protein ID: WP_000102537.1
Location: 1146986..1147204 (219 bp)
Type: Toxin
Protein ID: WP_001280991.1
Location: 1147209..1147604 (396 bp)
Type: Antitoxin
Protein ID: WP_000344801.1
Location: 1148161..1151310 (3150 bp)
Type: Others
Protein ID: WP_001132495.1
Location: 1151333..1152526 (1194 bp)
Type: Others
Protein ID: WP_001515899.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NFJ26_RS05310 (1142280)1142280..1142852+573WP_000779817.1YbaY family lipoprotein-
NFJ26_RS05315 (1142883)1142883..1143194-312WP_000409903.1MGMT family protein-
NFJ26_RS05325 (1143574)1143574..1143927+354WP_000878149.1DUF1428 domain-containing protein-
NFJ26_RS05330 (1143964)1143964..1145514-1551WP_001515896.1EAL domain-containing protein-
NFJ26_RS05335 (1145678)1145678..1146148-471WP_010379081.1YlaC family protein-
NFJ26_RS05340 (1146263)1146263..1146814-552WP_000102537.1maltose O-acetyltransferase-
NFJ26_RS05345 (1146986)1146986..1147204-219WP_001280991.1HHA domain-containing proteinToxin
NFJ26_RS05350 (1147209)1147209..1147604-396WP_000344801.1Hha toxicity modulator TomBAntitoxin
NFJ26_RS05355 (1148161)1148161..1151310-3150WP_001132495.1efflux RND transporter permease AcrB-
NFJ26_RS05360 (1151333)1151333..1152526-1194WP_001515899.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-117)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248594 WP_001280991.1 NZ_CP099351:c1147204-1146986 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT248594 WP_000344801.1 NZ_CP099351:c1147604-1147209 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB4ICG


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U9DNY0

References