Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1146986..1147604 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFJ26_RS05345 Protein ID WP_001280991.1
Coordinates 1146986..1147204 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag NFJ26_RS05350 Protein ID WP_000344801.1
Coordinates 1147209..1147604 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS05310 (1142280) 1142280..1142852 + 573 WP_000779817.1 YbaY family lipoprotein -
NFJ26_RS05315 (1142883) 1142883..1143194 - 312 WP_000409903.1 MGMT family protein -
NFJ26_RS05325 (1143574) 1143574..1143927 + 354 WP_000878149.1 DUF1428 domain-containing protein -
NFJ26_RS05330 (1143964) 1143964..1145514 - 1551 WP_001515896.1 EAL domain-containing protein -
NFJ26_RS05335 (1145678) 1145678..1146148 - 471 WP_010379081.1 YlaC family protein -
NFJ26_RS05340 (1146263) 1146263..1146814 - 552 WP_000102537.1 maltose O-acetyltransferase -
NFJ26_RS05345 (1146986) 1146986..1147204 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NFJ26_RS05350 (1147209) 1147209..1147604 - 396 WP_000344801.1 Hha toxicity modulator TomB Antitoxin
NFJ26_RS05355 (1148161) 1148161..1151310 - 3150 WP_001132495.1 efflux RND transporter permease AcrB -
NFJ26_RS05360 (1151333) 1151333..1152526 - 1194 WP_001515899.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248594 WP_001280991.1 NZ_CP099351:c1147204-1146986 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT248594 WP_000344801.1 NZ_CP099351:c1147604-1147209 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DNY0

References