Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 605055..605631 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag NFJ26_RS02780 Protein ID WP_105270768.1
Coordinates 605055..605342 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A7U9DAW4
Locus tag NFJ26_RS02785 Protein ID WP_000063150.1
Coordinates 605329..605631 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS02765 (600658) 600658..602019 - 1362 WP_000535394.1 restriction endonuclease subunit S -
NFJ26_RS02770 (602009) 602009..603628 - 1620 WP_001029742.1 class I SAM-dependent DNA methyltransferase -
NFJ26_RS02775 (603692) 603692..604858 - 1167 WP_000800829.1 restriction endonuclease -
NFJ26_RS02780 (605055) 605055..605342 + 288 WP_105270768.1 BrnT family toxin Toxin
NFJ26_RS02785 (605329) 605329..605631 + 303 WP_000063150.1 BrnA antitoxin family protein Antitoxin
NFJ26_RS02790 (605665) 605665..606621 - 957 WP_001297640.1 GTPase -
NFJ26_RS02795 (606632) 606632..606835 - 204 WP_000467859.1 YbdD/YjiX family protein -
NFJ26_RS02800 (606967) 606967..609117 - 2151 WP_061091154.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11110.64 Da        Isoelectric Point: 8.6424

>T248592 WP_105270768.1 NZ_CP099351:605055-605342 [Escherichia marmotae]
MPMEFEWDANKVKSNRVKHGIRFEDAVLVFDDPQHLSQQDRVGNGEYRWQTIGLVHGIVVILVAHIIRFESGNEIIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11532.03 Da        Isoelectric Point: 9.4646

>AT248592 WP_000063150.1 NZ_CP099351:605329-605631 [Escherichia marmotae]
MSMVKHKRGTPSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAW4

References