Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 393277..393773 Replicon chromosome
Accession NZ_CP099351
Organism Escherichia marmotae strain RHB02-E4-C07

Toxin (Protein)


Gene name ghoT Uniprot ID A0A7U9DCZ4
Locus tag NFJ26_RS01760 Protein ID WP_001173345.1
Coordinates 393600..393773 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A7U9DAJ1
Locus tag NFJ26_RS01755 Protein ID WP_001517605.1
Coordinates 393277..393573 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ26_RS01735 (390009) 390009..390728 - 720 WP_000611294.1 two-component system response regulator DcuR -
NFJ26_RS01740 (390725) 390725..392356 - 1632 WP_001216442.1 sensor histidine kinase -
NFJ26_RS01745 (392535) 392535..392765 + 231 WP_000371696.1 4Fe-4S mono-cluster protein YjdI -
NFJ26_RS01750 (392777) 392777..393049 + 273 WP_000405652.1 GNAT family N-acetyltransferase -
NFJ26_RS01755 (393277) 393277..393573 + 297 WP_001517605.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NFJ26_RS01760 (393600) 393600..393773 + 174 WP_001173345.1 type V toxin-antitoxin system toxin GhoT Toxin
NFJ26_RS01765 (393892) 393892..395409 - 1518 WP_001295074.1 lysine--tRNA ligase -
NFJ26_RS01770 (395646) 395646..397103 - 1458 WP_105270795.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 392777..402625 9848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(7-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T248591 WP_001173345.1 NZ_CP099351:393600-393773 [Escherichia marmotae]
MALFSKILIFYVIGVNISFVIIWFLSHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11568.18 Da        Isoelectric Point: 4.0994

>AT248591 WP_001517605.1 NZ_CP099351:393277-393573 [Escherichia marmotae]
MEGINRFKTYVVSFDYPSSYYSVFLRLRSLMYDMDFSSIVADEYGIPRQLNENAFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMIVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DCZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAJ1

References