Detailed information of TA system TA024859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 79483..80063
• Replicon: chromosome
• Accession: NC_014365
• Organism: Desulfarculus baarsii DSM 2075

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DEBA_RS00355
• Protein ID: WP_013256907.1
• Coordinates: 79483..79824 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: E1QDD3
• Locus tag: DEBA_RS00360
• Protein ID: WP_013256908.1
• Coordinates: 79821..80063 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEBA_RS00325	74767..76110	+	1344	WP_013256901.1	GAF domain-containing protein	-
DEBA_RS16545	76145..76654	-	510	WP_013256902.1	TlpA family protein disulfide reductase	-
DEBA_RS00335	76774..77598	+	825	WP_013256903.1	MBL fold metallo-hydrolase	-
DEBA_RS00340	77716..78462	+	747	WP_013256904.1	tetratricopeptide repeat protein	-
DEBA_RS00345	78589..78783	+	195	WP_043814783.1	ferredoxin	-
DEBA_RS00350	78786..79397	+	612	WP_013256906.1	rubrerythrin	-
DEBA_RS00355	79483..79824	-	342	WP_013256907.1	endoribonuclease MazF	Toxin
DEBA_RS00360	79821..80063	-	243	WP_013256908.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DEBA_RS00365	80146..80754	-	609	WP_013256909.1	hypothetical protein	-
DEBA_RS00370	80754..81215	-	462	WP_013256910.1	DoxX family membrane protein	-
DEBA_RS00375	81212..81688	-	477	WP_013256911.1	rhodanese domain protein	-
DEBA_RS00380	81843..82451	+	609	WP_013256912.1	flavodoxin family protein	-
DEBA_RS16550	82514..83056	+	543	WP_013256913.1	HAD hydrolase family protein	-
DEBA_RS16555	83059..83688	+	630	WP_013256914.1	DUF3786 domain-containing protein	-
DEBA_RS00395	83694..84260	+	567	WP_013256915.1	epoxyqueuosine reductase QueH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-110)

Antitoxin

• Antitoxin PemI-like (1-80)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 11972.82 Da
• Isoelectric Point: 8.9667

>T24859 WP_013256907.1 NC_014365:c79824-79483 [Desulfarculus baarsii DSM 2075]
VSQPYAPAAGDLVWLEFDPQAGGEQAGRRPALILSPLAYNQKTGLAIACPVTSHVKGYPFEVALPEDGKVRGVVLSDHVK
ILDWRARKAVKAGAAPSSVVDEVRARLAALLAF

Nucleotide

• Length: 342 bp

>T24859 NC_014365:c79824-79483 [Desulfarculus baarsii DSM 2075]
GTGAGCCAGCCCTACGCGCCCGCCGCCGGCGATCTGGTCTGGCTGGAGTTCGATCCCCAGGCCGGCGGCGAGCAGGCCGG
CCGGCGGCCGGCGCTGATCCTCTCGCCATTGGCTTACAACCAAAAAACCGGATTGGCCATCGCTTGCCCCGTGACCAGCC
ACGTCAAGGGCTATCCCTTCGAGGTGGCCTTGCCCGAGGACGGCAAGGTTCGGGGCGTTGTCTTGTCCGATCACGTCAAA
ATCCTGGACTGGCGGGCCAGGAAGGCCGTCAAGGCCGGCGCGGCCCCGTCAAGCGTGGTGGACGAGGTCCGCGCCAGGTT
GGCCGCGTTGCTGGCCTTCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8484.60 Da
• Isoelectric Point: 5.4811

>AT24859 WP_013256908.1 NC_014365:c80063-79821 [Desulfarculus baarsii DSM 2075]
MPNKVAKWGHSLAVRLPLQIVRQAGLKAGDNVTISAGQDGSVIIIPTRPQHDLDDLLGAITPDNLHGEADWGPAQGGEVW

Nucleotide

• Length: 243 bp

>AT24859 NC_014365:c80063-79821 [Desulfarculus baarsii DSM 2075]
ATGCCCAACAAGGTCGCCAAATGGGGCCATAGCCTGGCCGTGCGCCTGCCGTTGCAGATTGTCCGCCAGGCGGGCCTGAA
GGCCGGTGACAACGTGACGATCTCCGCCGGTCAGGACGGCTCGGTCATCATCATCCCCACGCGCCCCCAGCACGACTTGG
ACGACCTGCTCGGCGCGATCACCCCCGATAACCTGCATGGCGAGGCGGATTGGGGCCCGGCCCAGGGCGGTGAGGTTTGG
TGA

Structures

Antitoxin

• AlphaFold DB: E1QDD3