Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 79483..80063 Replicon chromosome
Accession NC_014365
Organism Desulfarculus baarsii DSM 2075

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DEBA_RS00355 Protein ID WP_013256907.1
Coordinates 79483..79824 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID E1QDD3
Locus tag DEBA_RS00360 Protein ID WP_013256908.1
Coordinates 79821..80063 (-) Length 81 a.a.

Genomic Context

DEBA_RS00325DEBA_RS00335DEBA_RS00340DEBA_RS00345DEBA_RS00350DEBA_RS00380DEBA_RS16550DEBA_RS16555DEBA_RS00395DEBA_RS16545DEBA_RS00355DEBA_RS00360DEBA_RS00365DEBA_RS00370DEBA_RS00375
Location: 74767..76110 (1344 bp)
Type: Others
Protein ID: WP_013256901.1
Location: 76774..77598 (825 bp)
Type: Others
Protein ID: WP_013256903.1
Location: 77716..78462 (747 bp)
Type: Others
Protein ID: WP_013256904.1
Location: 78589..78783 (195 bp)
Type: Others
Protein ID: WP_043814783.1
Location: 78786..79397 (612 bp)
Type: Others
Protein ID: WP_013256906.1
Location: 81843..82451 (609 bp)
Type: Others
Protein ID: WP_013256912.1
Location: 82514..83056 (543 bp)
Type: Others
Protein ID: WP_013256913.1
Location: 83059..83688 (630 bp)
Type: Others
Protein ID: WP_013256914.1
Location: 83694..84260 (567 bp)
Type: Others
Protein ID: WP_013256915.1
Location: 76145..76654 (510 bp)
Type: Others
Protein ID: WP_013256902.1
Location: 79483..79824 (342 bp)
Type: Toxin
Protein ID: WP_013256907.1
Location: 79821..80063 (243 bp)
Type: Antitoxin
Protein ID: WP_013256908.1
Location: 80146..80754 (609 bp)
Type: Others
Protein ID: WP_013256909.1
Location: 80754..81215 (462 bp)
Type: Others
Protein ID: WP_013256910.1
Location: 81212..81688 (477 bp)
Type: Others
Protein ID: WP_013256911.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DEBA_RS0032574767..76110+1344WP_013256901.1GAF domain-containing protein-
DEBA_RS1654576145..76654-510WP_013256902.1TlpA family protein disulfide reductase-
DEBA_RS0033576774..77598+825WP_013256903.1MBL fold metallo-hydrolase-
DEBA_RS0034077716..78462+747WP_013256904.1tetratricopeptide repeat protein-
DEBA_RS0034578589..78783+195WP_043814783.1ferredoxin-
DEBA_RS0035078786..79397+612WP_013256906.1rubrerythrin-
DEBA_RS0035579483..79824-342WP_013256907.1endoribonuclease MazFToxin
DEBA_RS0036079821..80063-243WP_013256908.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
DEBA_RS0036580146..80754-609WP_013256909.1hypothetical protein-
DEBA_RS0037080754..81215-462WP_013256910.1DoxX family membrane protein-
DEBA_RS0037581212..81688-477WP_013256911.1rhodanese domain protein-
DEBA_RS0038081843..82451+609WP_013256912.1flavodoxin family protein-
DEBA_RS1655082514..83056+543WP_013256913.1HAD hydrolase family protein-
DEBA_RS1655583059..83688+630WP_013256914.1DUF3786 domain-containing protein-
DEBA_RS0039583694..84260+567WP_013256915.1epoxyqueuosine reductase QueH-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-110)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 11972.82 Da        Isoelectric Point: 8.9667

>T24859 WP_013256907.1 NC_014365:c79824-79483 [Desulfarculus baarsii DSM 2075]
VSQPYAPAAGDLVWLEFDPQAGGEQAGRRPALILSPLAYNQKTGLAIACPVTSHVKGYPFEVALPEDGKVRGVVLSDHVK
ILDWRARKAVKAGAAPSSVVDEVRARLAALLAF

Download         Length: 342 bp

>T24859 NC_014365:c79824-79483 [Desulfarculus baarsii DSM 2075]
GTGAGCCAGCCCTACGCGCCCGCCGCCGGCGATCTGGTCTGGCTGGAGTTCGATCCCCAGGCCGGCGGCGAGCAGGCCGG
CCGGCGGCCGGCGCTGATCCTCTCGCCATTGGCTTACAACCAAAAAACCGGATTGGCCATCGCTTGCCCCGTGACCAGCC
ACGTCAAGGGCTATCCCTTCGAGGTGGCCTTGCCCGAGGACGGCAAGGTTCGGGGCGTTGTCTTGTCCGATCACGTCAAA
ATCCTGGACTGGCGGGCCAGGAAGGCCGTCAAGGCCGGCGCGGCCCCGTCAAGCGTGGTGGACGAGGTCCGCGCCAGGTT
GGCCGCGTTGCTGGCCTTCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8484.60 Da        Isoelectric Point: 5.4811

>AT24859 WP_013256908.1 NC_014365:c80063-79821 [Desulfarculus baarsii DSM 2075]
MPNKVAKWGHSLAVRLPLQIVRQAGLKAGDNVTISAGQDGSVIIIPTRPQHDLDDLLGAITPDNLHGEADWGPAQGGEVW

Download         Length: 243 bp

>AT24859 NC_014365:c80063-79821 [Desulfarculus baarsii DSM 2075]
ATGCCCAACAAGGTCGCCAAATGGGGCCATAGCCTGGCCGTGCGCCTGCCGTTGCAGATTGTCCGCCAGGCGGGCCTGAA
GGCCGGTGACAACGTGACGATCTCCGCCGGTCAGGACGGCTCGGTCATCATCATCCCCACGCGCCCCCAGCACGACTTGG
ACGACCTGCTCGGCGCGATCACCCCCGATAACCTGCATGGCGAGGCGGATTGGGGCCCGGCCCAGGGCGGTGAGGTTTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBE1QDD3

References