Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4234352..4234977 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag NFJ86_RS20375 Protein ID WP_000911329.1
Coordinates 4234579..4234977 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NFJ86_RS20370 Protein ID WP_000450524.1
Coordinates 4234352..4234579 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS20345 (4230154) 4230154..4230624 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
NFJ86_RS20350 (4230624) 4230624..4231196 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
NFJ86_RS20355 (4231343) 4231343..4232221 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
NFJ86_RS20360 (4232238) 4232238..4233272 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
NFJ86_RS20365 (4233484) 4233484..4234197 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NFJ86_RS20370 (4234352) 4234352..4234579 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NFJ86_RS20375 (4234579) 4234579..4234977 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
NFJ86_RS20380 (4235124) 4235124..4235987 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NFJ86_RS20385 (4236002) 4236002..4238017 + 2016 WP_181203253.1 tRNA cytosine(34) acetyltransferase TmcA -
NFJ86_RS20390 (4238091) 4238091..4238792 + 702 WP_105288162.1 esterase -
NFJ86_RS20395 (4238887) 4238887..4239087 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T248588 WP_000911329.1 NZ_CP099349:4234579-4234977 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT248588 WP_000450524.1 NZ_CP099349:4234352-4234579 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References