Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3394032..3394554 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name relE Uniprot ID A0A7W3EN85
Locus tag NFJ86_RS16400 Protein ID WP_046083069.1
Coordinates 3394264..3394554 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7LMQ7
Locus tag NFJ86_RS16395 Protein ID WP_000212726.1
Coordinates 3394032..3394274 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS16375 (3389881) 3389881..3391254 + 1374 WP_001219809.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
NFJ86_RS16380 (3391405) 3391405..3391956 - 552 WP_000166277.1 ribosome biogenesis factor YjgA -
NFJ86_RS16385 (3392050) 3392050..3393402 + 1353 WP_001162171.1 metalloprotease PmbA -
NFJ86_RS16390 (3393455) 3393455..3393841 + 387 WP_001232246.1 cytochrome b562 -
NFJ86_RS16395 (3394032) 3394032..3394274 + 243 WP_000212726.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFJ86_RS16400 (3394264) 3394264..3394554 + 291 WP_046083069.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFJ86_RS16405 (3394555) 3394555..3395019 - 465 WP_001106232.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFJ86_RS16410 (3395177) 3395177..3397315 - 2139 WP_000187805.1 anaerobic ribonucleoside-triphosphate reductase -
NFJ86_RS16415 (3397709) 3397709..3399364 - 1656 WP_181203089.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11323.22 Da        Isoelectric Point: 10.3007

>T248583 WP_046083069.1 NZ_CP099349:3394264-3394554 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9140.53 Da        Isoelectric Point: 5.1369

>AT248583 WP_000212726.1 NZ_CP099349:3394032-3394274 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRQLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EN85

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3HXN7

References