Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1867367..1868021 Replicon chromosome
Accession NZ_CP099349
Organism Escherichia fergusonii strain RHB16-E2-C07

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NFJ86_RS09205 Protein ID WP_000244781.1
Coordinates 1867367..1867774 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NFJ86_RS09210 Protein ID WP_000354046.1
Coordinates 1867755..1868021 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ86_RS09185 (1863324) 1863324..1865057 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
NFJ86_RS09190 (1865063) 1865063..1865773 - 711 WP_104917537.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ86_RS09195 (1865798) 1865798..1866694 - 897 WP_000806645.1 site-specific tyrosine recombinase XerD -
NFJ86_RS09200 (1866806) 1866806..1867327 + 522 WP_001055874.1 flavodoxin FldB -
NFJ86_RS09205 (1867367) 1867367..1867774 - 408 WP_000244781.1 protein YgfX Toxin
NFJ86_RS09210 (1867755) 1867755..1868021 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NFJ86_RS09215 (1868273) 1868273..1869253 + 981 WP_181202810.1 tRNA-modifying protein YgfZ -
NFJ86_RS09220 (1869330) 1869330..1869989 - 660 WP_000250283.1 hemolysin III family protein -
NFJ86_RS09225 (1870153) 1870153..1870464 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
NFJ86_RS09230 (1870509) 1870509..1871942 + 1434 WP_148047390.1 6-phospho-beta-glucosidase BglA -
NFJ86_RS09235 (1871990) 1871990..1872883 - 894 WP_000819362.1 transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T248578 WP_000244781.1 NZ_CP099349:c1867774-1867367 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT248578 WP_000354046.1 NZ_CP099349:c1868021-1867755 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PAM6


Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References