248570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 3049..3523 Replicon plasmid unnamed3
Accession NZ_CP099347
Organism Escherichia marmotae strain RHB35-E2-C08

Toxin (Protein)


Gene name pasB Uniprot ID S1DZ70
Locus tag NFK54_RS24695 Protein ID WP_000262326.1
Coordinates 3257..3523 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag NFK54_RS24690 Protein ID WP_167780126.1
Coordinates 3049..3273 (+) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK54_RS24675 (NFK54_24580) 1820..2134 - 315 WP_024139128.1 hypothetical protein -
NFK54_RS24680 (NFK54_24585) 2235..2537 - 303 WP_167780124.1 hypothetical protein -
NFK54_RS24685 (NFK54_24590) 2642..2890 - 249 WP_167780125.1 hypothetical protein -
NFK54_RS24690 (NFK54_24595) 3049..3273 + 225 WP_167780126.1 DUF6290 family protein Antitoxin
NFK54_RS24695 (NFK54_24600) 3257..3523 + 267 WP_000262326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFK54_RS24700 (NFK54_24605) 3629..3799 - 171 WP_163448562.1 hypothetical protein -
NFK54_RS24705 (NFK54_24610) 3993..4412 - 420 WP_279283709.1 Exc2 family lipoprotein -
NFK54_RS24710 (NFK54_24615) 4493..4930 - 438 WP_024166928.1 hypothetical protein -
NFK54_RS24715 (NFK54_24620) 5188..6756 + 1569 WP_096129440.1 pore-forming bacteriocin colicin E1 -
NFK54_RS24720 (NFK54_24625) 6753..6980 - 228 WP_279283710.1 colicin E1 immunity protein -
NFK54_RS24725 (NFK54_24630) 7142..7279 + 138 WP_096129442.1 colicin release lysis protein -
NFK54_RS24730 (NFK54_24635) 8166..8363 - 198 WP_105453999.1 Rop family plasmid primer RNA-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11780 11780
- flank IS/Tn - - 126..551 425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-87)

Antitoxin

(4-45)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10385.00 Da        Isoelectric Point: 9.5211

>T248570 WP_000262326.1 NZ_CP099347:3257-3523 [Escherichia marmotae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMDLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRILCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp


Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.31 Da        Isoelectric Point: 4.8307

>AT248570 WP_167780126.1 NZ_CP099347:3049-3273 [Escherichia marmotae]
MLAIRLSAEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEPVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1DZ70


Antitoxin

Source ID Structure

References