Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 84163..84788 Replicon plasmid unnamed1
Accession NZ_CP099345
Organism Escherichia marmotae strain RHB35-E2-C08

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFK54_RS24155 Protein ID WP_000911306.1
Coordinates 84163..84561 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D6IDB0
Locus tag NFK54_RS24160 Protein ID WP_000450523.1
Coordinates 84561..84788 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK54_RS24135 (81359) 81359..82006 + 648 WP_097456829.1 hypothetical protein -
NFK54_RS24140 (82078) 82078..82815 + 738 WP_000926075.1 conjugal transfer complement resistance protein TraT -
NFK54_RS24145 (82943) 82943..83506 + 564 WP_279283671.1 hypothetical protein -
NFK54_RS24150 (83778) 83778..84146 + 369 WP_245146932.1 DUF2726 domain-containing protein -
NFK54_RS24155 (84163) 84163..84561 - 399 WP_000911306.1 type II toxin-antitoxin system VapC family toxin Toxin
NFK54_RS24160 (84561) 84561..84788 - 228 WP_000450523.1 toxin-antitoxin system antitoxin VapB Antitoxin
NFK54_RS24165 (84921) 84921..87107 + 2187 WP_000099426.1 type IV conjugative transfer system coupling protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pefD 1..98156 98156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14958.31 Da        Isoelectric Point: 8.1432

>T248566 WP_000911306.1 NZ_CP099345:c84561-84163 [Escherichia marmotae]
MLKFMLDTNICIFTIKNKPAHIRERFNLNSGRMCISSVTVMELVYGAEKSQFPERNLAIIEGFISRLDVLDYDCAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERIAGLRLEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8398.39 Da        Isoelectric Point: 4.3719

>AT248566 WP_000450523.1 NZ_CP099345:c84788-84561 [Escherichia marmotae]
METTVFLSNRSQAVRLPKAVALPEDVKKVDVIAVGRTRIITPAGESWDSWFDGDSVSADFMNDREQPAVQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6LFS1

References