Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4312150..4312768 Replicon chromosome
Accession NZ_CP099344
Organism Escherichia marmotae strain RHB35-E2-C08

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFK54_RS20925 Protein ID WP_001280991.1
Coordinates 4312150..4312368 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U9DNY0
Locus tag NFK54_RS20930 Protein ID WP_000344801.1
Coordinates 4312373..4312768 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK54_RS20890 (4307444) 4307444..4308016 + 573 WP_000779815.1 YbaY family lipoprotein -
NFK54_RS20895 (4308047) 4308047..4308358 - 312 WP_000409903.1 MGMT family protein -
NFK54_RS20905 (4308738) 4308738..4309091 + 354 WP_000878149.1 DUF1428 domain-containing protein -
NFK54_RS20910 (4309128) 4309128..4310678 - 1551 WP_115775484.1 EAL domain-containing protein -
NFK54_RS20915 (4310842) 4310842..4311312 - 471 WP_001515897.1 YlaC family protein -
NFK54_RS20920 (4311427) 4311427..4311978 - 552 WP_000102537.1 maltose O-acetyltransferase -
NFK54_RS20925 (4312150) 4312150..4312368 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NFK54_RS20930 (4312373) 4312373..4312768 - 396 WP_000344801.1 Hha toxicity modulator TomB Antitoxin
NFK54_RS20935 (4313325) 4313325..4316474 - 3150 WP_001132495.1 efflux RND transporter permease AcrB -
NFK54_RS20940 (4316497) 4316497..4317690 - 1194 WP_001515899.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248562 WP_001280991.1 NZ_CP099344:c4312368-4312150 [Escherichia marmotae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 15393.22 Da        Isoelectric Point: 4.9228

>AT248562 WP_000344801.1 NZ_CP099344:c4312768-4312373 [Escherichia marmotae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSCSNYYNHG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DNY0

References