Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3403476..3403972 Replicon chromosome
Accession NZ_CP099344
Organism Escherichia marmotae strain RHB35-E2-C08

Toxin (Protein)


Gene name ghoT Uniprot ID A0A7U9DCZ4
Locus tag NFK54_RS16645 Protein ID WP_001173345.1
Coordinates 3403799..3403972 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A7U9DAJ1
Locus tag NFK54_RS16640 Protein ID WP_001517605.1
Coordinates 3403476..3403772 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK54_RS16620 (3400208) 3400208..3400927 - 720 WP_000611294.1 two-component system response regulator DcuR -
NFK54_RS16625 (3400924) 3400924..3402555 - 1632 WP_001216442.1 sensor histidine kinase -
NFK54_RS16630 (3402734) 3402734..3402964 + 231 WP_000371696.1 4Fe-4S mono-cluster protein YjdI -
NFK54_RS16635 (3402976) 3402976..3403248 + 273 WP_000405652.1 GNAT family N-acetyltransferase -
NFK54_RS16640 (3403476) 3403476..3403772 + 297 WP_001517605.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NFK54_RS16645 (3403799) 3403799..3403972 + 174 WP_001173345.1 type V toxin-antitoxin system toxin GhoT Toxin
NFK54_RS16650 (3404091) 3404091..3405608 - 1518 WP_001295074.1 lysine--tRNA ligase -
NFK54_RS16655 (3405845) 3405845..3407302 - 1458 WP_001517606.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3403476..3429890 26414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(7-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T248559 WP_001173345.1 NZ_CP099344:3403799-3403972 [Escherichia marmotae]
MALFSKILIFYVIGVNISFVIIWFLSHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11568.18 Da        Isoelectric Point: 4.0994

>AT248559 WP_001517605.1 NZ_CP099344:3403476-3403772 [Escherichia marmotae]
MEGINRFKTYVVSFDYPSSYYSVFLRLRSLMYDMDFSSIVADEYGIPRQLNENAFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMIVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DCZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DAJ1

References